OpenClaim

Norgestimate Side Effects

The most commonly reported side effects of norgestimate include nausea, anxiety, and headache, based on 9,654 FDA adverse event reports from 2004 to 2025. 4.6% of reports found the drug to be ineffective.

Norgestimate side effects

Percentages show how often each reaction appears relative to total reports for norgestimate.

1
Nausea5.4%526
2
Drug Ineffective4.6%445
3
Anxiety3.9%378
4
Headache3.9%377
5
Pregnancy On Oral Contraceptive3.8%367
6
Pain3.8%366
7
Drug Exposure During Pregnancy3.5%339
8
Fatigue3.5%338
9
Vomiting2.8%272
10
Nausea2.8%267
11
Dizziness2.5%243
12
Depression2.3%225
13
Diarrhoea2.1%206
14
Off Label Use2.1%203
15
Rash2.0%197

These are voluntary reports and do not establish that norgestimate caused these reactions.

Report severity

56.0%Serious5,408 reports
20.3%Hospitalizations1,960 reports
2.7%Fatal261 reports

Seriousness is determined by the reporter, not by OpenClaim.

Norgestimate drug interactions

Other drugs that appear in adverse event reports alongside norgestimate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol39.7%3,831
2
Sodium-oxybate5.7%554
3
Adalimumab4.8%460
4
Levonorgestrel4.5%434
5
Drospirenone3.8%369
6
Isotretinoin3.7%360
7
Dupilumab3.3%316
8
Norethindrone3.2%313
9
Estradiol3.1%297
10
Medroxyprogesterone-acetate2.9%281
11
Estrogens2.9%279
12
Progesterone1.4%135
13
Desogestrel1.2%119
14
Etanercept1.1%104
15
Fingolimod1.1%103

Taken alongside

1
Ethinyl-estradiol59.9%5,782
2
Acetaminophen7.9%760
3
Ergocalciferol6.5%627
4
Albuterol6.2%600
5
Ibuprofen6.0%575
6
Levothyroxine-sodium5.5%529
7
Fluticasone5.3%511
8
Omeprazole4.6%445
9
Cetirizine-hydrochloride4.2%401
10
Prednisone4.1%400
11
Sertraline-hydrochloride3.6%343
12
Pantoprazole-sodium3.5%338
13
Montelukast-sodium3.5%336
14
Aspirin3.4%330
15
Dextroamphetamine3.3%320

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports norgestimate side effects

87.9% of norgestimate adverse event reports involve female patients and 5.3% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female87.9%
Male5.3%
Unknown6.8%

Age group

< 20.3%
2–110.2%
12–176.1%
18–6486.2%
65+7.2%

What is norgestimate used for

Conditions and purposes for which patients were taking norgestimate when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAbnormal Uterine BleedingAcneAcne CysticAdenomyosisAdrenal InsufficiencyAdverse EventAffective DisorderAlopeciaAmenorrhoeaAnaemiaAngina PectorisAnkylosing SpondylitisAnovulatory Cycle

Showing 15 of 212 indications

Norgestimate brand names and reporting trend

Norgestimate is sold under the brand name Estradiol And Norgestimate.

Brand names

Estradiol And Norgestimate257

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking norgestimate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.