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Norfloxacin Side Effects

The most commonly reported side effects of norfloxacin include fatigue, dizziness, and nausea, based on 2,452 FDA adverse event reports from 2004 to 2025.

Norfloxacin side effects

Percentages show how often each reaction appears relative to total reports for norfloxacin.

1
Fatigue14.4%353
2
Dizziness13.1%322
3
Nausea13.0%318
4
Vomiting12.6%308
5
Arthralgia11.1%271
6
Malaise10.9%268
7
Dyspnoea10.6%259
8
Headache10.5%257
9
Pruritus10.4%255
10
Diarrhoea10.3%252
11
Fall10.2%249
12
Tachycardia10.1%248
13
Ascites10.0%244
14
Asthenia9.9%243
15
Sepsis9.8%241

These are voluntary reports and do not establish that norfloxacin caused these reactions.

Report severity

97.1%Serious2,380 reports
51.6%Hospitalizations1,266 reports
23.7%Fatal581 reports

Seriousness is determined by the reporter, not by OpenClaim.

Norfloxacin drug interactions

Other drugs that appear in adverse event reports alongside norfloxacin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pregabalin18.0%442
2
Adalimumab17.9%438
3
Celecoxib17.7%434
4
Bisoprolol-fumarate17.6%431
5
Acetaminophen14.7%360
6
Ribavirin14.4%354
7
Sofosbuvir13.1%320
8
Simvastatin12.9%316
9
Escitalopram-oxalate12.6%310
10
Enoxaparin-sodium12.6%309
11
Hydrochlorothiazide12.4%304
12
Verapamil-hydrochloride12.2%298
13
Aspirin12.1%296
14
Diltiazem12.0%295
15
Tocilizumab12.0%295

Taken alongside

1
Furosemide8.0%195
2
Acetaminophen7.8%191
3
Omeprazole7.0%172
4
Spironolactone6.8%166
5
Aspirin5.1%125
6
Prednisone4.6%114
7
Levothyroxine-sodium4.4%109
8
Lactulose3.9%96
9
Esomeprazole3.8%92
10
Sulfamethoxazole3.4%84
11
Pantoprazole-sodium3.4%83
12
Metformin3.3%81
13
Amoxicillin3.1%77
14
Trimethoprim3.1%77
15
Folic-acid3.1%76

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports norfloxacin side effects

51.3% of norfloxacin adverse event reports involve female patients and 29.4% involve male patients. The largest age group is adult at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.3%
Male29.4%
Unknown19.3%

Age group

< 21.4%
2–110.6%
12–171.4%
18–6448.7%
65+47.8%

What is norfloxacin used for

Conditions and purposes for which patients were taking norfloxacin when the adverse event was reported.

Abdominal PainAcute SinusitisAdenocarcinoma PancreasAntibiotic ProphylaxisAntibiotic TherapyArthralgiaArthritis InfectiveAscitesAbdominal PainAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyBacterial PyelonephritisBacterial SepsisBladder Pain

Showing 15 of 171 indications

Norfloxacin brand names and reporting trend

Norfloxacin is sold under the brand name Noroxin.

Brand names

Noroxin2,102

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking norfloxacin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.