OpenClaim

Norepinephrine Side Effects

The most commonly reported side effects of norepinephrine include renal failure, pain, and injury, based on 3,721 FDA adverse event reports from 2004 to 2025. 10.2% of reports found the drug to be ineffective.

Norepinephrine side effects

Percentages show how often each reaction appears relative to total reports for norepinephrine.

1
Renal Failure11.1%412
2
Pain10.3%383
3
Drug Ineffective10.2%381
4
Injury9.4%351
5
Anxiety8.8%328
6
Unevaluable Event8.8%327
7
Fear7.9%295
8
Hypotension7.7%286
9
Condition Aggravated7.4%276
10
Emotional Distress7.0%260
11
Off Label Use6.8%253
12
Sepsis6.5%242
13
Renal Injury6.5%242
14
Multi-organ Failure6.3%236
15
Multiple Organ Dysfunction Syndrome6.2%231

These are voluntary reports and do not establish that norepinephrine caused these reactions.

Report severity

94.0%Serious3,498 reports
45.4%Hospitalizations1,690 reports
41.3%Fatal1,535 reports

Seriousness is determined by the reporter, not by OpenClaim.

Norepinephrine drug interactions

Other drugs that appear in adverse event reports alongside norepinephrine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Epinephrine10.5%392
2
Aprotinin10.5%391
3
Heparin9.2%342
4
Acetaminophen8.9%331
5
Vasopressin8.8%328
6
Ceftriaxone-sodium7.6%283
7
Propofol7.6%281
8
Dobutamine-hydrochloride7.4%275
9
Amiodarone-hydrochloride7.2%269
10
Hydrocortisone7.0%262
11
Albuterol6.4%238
12
Insulin6.2%229
13
Ondansetron6.0%223
14
Lansoprazole5.6%210
15
Vancomycin5.5%204

Taken alongside

1
Furosemide20.7%772
2
Heparin18.6%693
3
Midazolam17.7%657
4
Fentanyl16.5%613
5
Vancomycin16.4%612
6
Insulin15.2%567
7
Acetaminophen14.2%530
8
Propofol12.7%474
9
Potassium-chloride12.7%472
10
Epinephrine12.4%462
11
Pantoprazole-sodium11.6%432
12
Vasopressin10.6%394
13
Metoprolol10.0%372
14
Dopamine-hydrochloride9.6%357
15
Sodium-chloride9.6%357

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports norepinephrine side effects

37.9% of norepinephrine adverse event reports involve female patients and 51.5% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.9%
Male51.5%
Unknown10.6%

Age group

< 21.8%
2–111.1%
12–172.7%
18–6451.4%
65+43.1%

What is norepinephrine used for

Conditions and purposes for which patients were taking norepinephrine when the adverse event was reported.

Abdominal PainAcute Kidney InjuryAcute Myocardial InfarctionAcute Respiratory Distress SyndromeAdverse EventAnaphylactic ReactionAnaphylactic ShockArrhythmiaAstheniaAtrial FibrillationAbdominal AbscessAcidosisAcute Kidney InjuryAcute Left Ventricular FailureAcute Respiratory Distress Syndrome

Showing 15 of 336 indications

Norepinephrine brand names and reporting trend

Norepinephrine is sold under the brand name Levophed.

Brand names

Levophed3,546

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking norepinephrine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.