OpenClaim

Norelgestromin Side Effects

The most commonly reported side effects of norelgestromin include metrorrhagia, nausea, and application site reaction, based on 17,183 FDA adverse event reports from 2004 to 2025.

Norelgestromin side effects

Percentages show how often each reaction appears relative to total reports for norelgestromin.

1
Metrorrhagia15.8%2,718
2
Nausea6.7%1,152
3
Application Site Reaction6.3%1,074
4
Pulmonary Embolism6.1%1,054
5
Product Adhesion Issue4.9%843
6
Deep Vein Thrombosis4.7%813
7
Drug Exposure During Pregnancy4.7%800
8
Product Quality Issue4.1%698
9
Unintended Pregnancy4.0%682
10
Headache3.6%617
11
Inappropriate Schedule Of Drug Administration3.4%584
12
Drug Dose Omission2.9%505
13
Oligomenorrhoea2.5%432
14
Vomiting2.4%416
15
Breast Tenderness2.3%403

These are voluntary reports and do not establish that norelgestromin caused these reactions.

Report severity

31.1%Serious5,337 reports
13.0%Hospitalizations2,241 reports
1.1%Fatal196 reports

Seriousness is determined by the reporter, not by OpenClaim.

Norelgestromin drug interactions

Other drugs that appear in adverse event reports alongside norelgestromin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol95.7%16,438
2
Levonorgestrel0.4%67
3
Sodium-oxybate0.3%59
4
Adalimumab0.3%47
5
Drospirenone0.3%43
6
Norgestimate0.2%41
7
Etonogestrel0.2%37
8
Dupilumab0.2%33
9
Isotretinoin0.2%29
10
Topiramate0.1%22
11
Sertraline-hydrochloride0.1%21
12
Infliximab0.1%19
13
Venlafaxine<0.1%16
14
Interferon<0.1%16
15
Medroxyprogesterone-acetate<0.1%16

Taken alongside

1
Ethinyl-estradiol4.5%778
2
Acetaminophen2.0%336
3
Ibuprofen1.6%270
4
Albuterol1.3%231
5
Levothyroxine-sodium1.3%228
6
Sertraline-hydrochloride1.0%180
7
Cetirizine-hydrochloride1.0%164
8
Fluticasone0.9%162
9
Escitalopram-oxalate0.8%135
10
Fexofenadine-hydrochloride0.8%132
11
Bupropion0.8%129
12
Buspirone-hydrochloride0.7%120
13
Hydrocodone0.7%118
14
Naproxen0.7%112
15
Montelukast-sodium0.6%98

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports norelgestromin side effects

98.6% of norelgestromin adverse event reports involve female patients and 0.3% involve male patients. The largest age group is adult at 93%. These figures reflect who reports side effects, not underlying risk.

Sex

Female98.6%
Male0.3%
Unknown1.1%

Age group

< 20.2%
2–110.2%
12–176.8%
18–6492.7%
65+<0.1%

What is norelgestromin used for

Conditions and purposes for which patients were taking norelgestromin when the adverse event was reported.

Abdominal PainAccidental ExposureAccidental Exposure To ProductAcneAcne CysticAdnexa Uteri MassAdnexa Uteri PainAffective DisorderAmenorrhoeaAnaemiaAngerAnxietyAsthmaAutoimmune DisorderAutonomic Nervous System Imbalance

Showing 15 of 170 indications

Norelgestromin brand names and reporting trend

Norelgestromin is sold under the brand name Onsura.

Brand names

Onsura34

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking norelgestromin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.