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Nonoxynol Side Effects

The most commonly reported side effects of nonoxynol include pregnancy with contraceptive device, abortion spontaneous, and maternal exposure during pregnancy, based on 15 FDA adverse event reports from 2007 to 2024. 6.7% of reports found the drug to be ineffective.

Nonoxynol side effects

Percentages show how often each reaction appears relative to total reports for nonoxynol.

1
Pregnancy With Contraceptive Device26.7%4
2
Abortion Spontaneous20.0%3
3
Maternal Exposure During Pregnancy13.3%2
4
Dyspnoea6.7%1
5
Pruritus Generalised6.7%1
6
Device Failure6.7%1
7
Device Ineffective6.7%1
8
Drug Exposure During Pregnancy6.7%1
9
Pharmaceutical Product Complaint6.7%1
10
Hypersensitivity6.7%1
11
Medical Device Complication6.7%1
12
Vaginal Haemorrhage6.7%1
13
Vaginal Swelling6.7%1
14
Vulvovaginal Pain6.7%1
15
Toxic Shock Syndrome6.7%1

These are voluntary reports and do not establish that nonoxynol caused these reactions.

Report severity

53.3%Serious8 reports
0.0%Hospitalizations0 reports
6.7%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nonoxynol drug interactions

Other drugs that appear in adverse event reports alongside nonoxynol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pregabalin6.7%1
2
Methylprednisolone6.7%1
3
Copper6.7%1
4
Dimethyl6.7%1

Taken alongside

1
Levothyroxine-sodium6.7%1
2
Trazodone-hydrochloride6.7%1
3
Clonazepam6.7%1
4
Temazepam6.7%1
5
Bupropion6.7%1
6
Losartan-potassium6.7%1
7
Acetaminophen6.7%1
8
Hydrocodone6.7%1
9
Alprazolam6.7%1
10
Cetirizine-hydrochloride6.7%1
11
Montelukast-sodium6.7%1
12
Escitalopram-oxalate6.7%1
13
Albuterol6.7%1
14
Amphetamine6.7%1
15
Dextroamphetamine6.7%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nonoxynol side effects

93.3% of nonoxynol adverse event reports involve female patients and 6.7% involve male patients. The largest age group is adult at 92%. These figures reflect who reports side effects, not underlying risk.

Sex

Female93.3%
Male6.7%
Unknown0.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6492.3%
65+7.7%

What is nonoxynol used for

Conditions and purposes for which patients were taking nonoxynol when the adverse event was reported.

ContraceptionContraceptionProduct Used For Unknown Indication

Nonoxynol brand names and reporting trend

Nonoxynol is sold under the brand name Delfen.

Brand names

Delfen8

Quarterly reports (20072024)

20072024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nonoxynol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.