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Nitroglycerin Side Effects

The most commonly reported side effects of nitroglycerin include dyspnoea, fatigue, and nausea, based on 71,633 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Nitroglycerin side effects

Percentages show how often each reaction appears relative to total reports for nitroglycerin.

1
Dyspnoea5.6%4,006
2
Fatigue5.0%3,615
3
Nausea4.4%3,125
4
Drug Ineffective4.3%3,054
5
Fall4.2%3,033
6
Dizziness4.1%2,942
7
Myocardial Infarction3.9%2,802
8
Pain3.9%2,790
9
Diarrhoea3.9%2,775
10
Headache3.7%2,676
11
Chest Pain3.5%2,527
12
Off Label Use3.4%2,437
13
Malaise3.2%2,314
14
Hypotension3.2%2,313
15
Death3.1%2,191

These are voluntary reports and do not establish that nitroglycerin caused these reactions.

Report severity

81.6%Serious58,453 reports
47.2%Hospitalizations33,779 reports
12.7%Fatal9,116 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nitroglycerin drug interactions

Other drugs that appear in adverse event reports alongside nitroglycerin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin5.3%3,777
2
Omeprazole4.5%3,257
3
Furosemide4.0%2,843
4
Lenalidomide3.3%2,368
5
Atorvastatin-calcium3.3%2,335
6
Amlodipine3.1%2,255
7
Rosiglitazone-maleate2.9%2,101
8
Acetaminophen2.9%2,082
9
Pantoprazole-sodium2.7%1,948
10
Rosuvastatin2.7%1,938
11
Esomeprazole2.7%1,926
12
Adalimumab2.7%1,913
13
Diltiazem2.3%1,640
14
Tiotropium-bromide2.2%1,576
15
Albuterol2.2%1,562

Taken alongside

1
Aspirin41.0%29,371
2
Furosemide25.1%17,987
3
Atorvastatin-calcium23.9%17,136
4
Metoprolol23.1%16,531
5
Acetaminophen22.5%16,110
6
Albuterol16.6%11,898
7
Amlodipine15.4%11,011
8
Omeprazole14.5%10,381
9
Isosorbide14.3%10,237
10
Lisinopril13.5%9,684
11
Levothyroxine-sodium13.4%9,582
12
Ergocalciferol12.7%9,129
13
Clopidogrel-bisulfate12.6%9,003
14
Pantoprazole-sodium12.1%8,703
15
Insulin12.1%8,698

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nitroglycerin side effects

45.2% of nitroglycerin adverse event reports involve female patients and 48.0% involve male patients. The largest age group is elderly at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.2%
Male48.0%
Unknown6.8%

Age group

< 20.4%
2–110.2%
12–170.1%
18–6435.7%
65+63.7%

What is nitroglycerin used for

Conditions and purposes for which patients were taking nitroglycerin when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAbdominal Pain UpperAbnormal EcgAccidental Exposure To ProductAcneAcute Coronary SyndromeAcute Kidney InjuryAcute Myocardial InfarctionAcute Pulmonary OedemaAcute TonsillitisAdjuvant TherapyAdverse EventAge Indeterminate Myocardial InfarctionAgranulocytosis

Showing 15 of 814 indications

Nitroglycerin brand names and reporting trend

Nitroglycerin is sold under the brand name Nitro Iv.

Brand names

Nitro Iv57,853

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nitroglycerin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.