OpenClaim

Nifedipine Side Effects

The most commonly reported side effects of nifedipine include diarrhoea, fatigue, and dyspnoea, based on 59,252 FDA adverse event reports from 2004 to 2025. 4.0% of reports found the drug to be ineffective.

Nifedipine side effects

Percentages show how often each reaction appears relative to total reports for nifedipine.

1
Drug Ineffective4.0%2,378
2
Diarrhoea4.0%2,342
3
Fatigue3.9%2,317
4
Dyspnoea3.9%2,298
5
Off Label Use3.9%2,286
6
Nausea3.5%2,070
7
Headache3.3%1,933
8
Hypertension2.9%1,706
9
Acute Kidney Injury2.8%1,656
10
Dizziness2.7%1,624
11
Death2.6%1,557
12
Pneumonia2.6%1,549
13
Pain2.6%1,511
14
Malaise2.4%1,415
15
Asthenia2.3%1,383

These are voluntary reports and do not establish that nifedipine caused these reactions.

Report severity

80.8%Serious47,847 reports
43.4%Hospitalizations25,697 reports
12.1%Fatal7,155 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nifedipine drug interactions

Other drugs that appear in adverse event reports alongside nifedipine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin2.7%1,573
2
Lenalidomide2.6%1,526
3
Omeprazole2.3%1,375
4
Adalimumab2.1%1,234
5
Tacrolimus2.0%1,198
6
Prednisone2.0%1,197
7
Esomeprazole1.9%1,130
8
Valsartan1.8%1,071
9
Metformin1.8%1,060
10
Metoprolol1.8%1,055
11
Furosemide1.7%1,015
12
Treprostinil1.7%1,003
13
Mycophenolate1.7%996
14
Amlodipine1.6%931
15
Rituximab1.6%926

Taken alongside

1
Aspirin18.1%10,717
2
Furosemide14.2%8,437
3
Atorvastatin-calcium11.7%6,924
4
Acetaminophen11.5%6,836
5
Metoprolol10.5%6,239
6
Levothyroxine-sodium8.9%5,276
7
Omeprazole8.7%5,147
8
Ergocalciferol8.6%5,111
9
Prednisone8.5%5,015
10
Hydrochlorothiazide7.7%4,556
11
Lisinopril7.6%4,512
12
Insulin7.6%4,477
13
Metformin7.1%4,214
14
Losartan-potassium6.6%3,896
15
Pantoprazole-sodium6.5%3,865

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nifedipine side effects

51.6% of nifedipine adverse event reports involve female patients and 40.8% involve male patients. The largest age group is elderly at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.6%
Male40.8%
Unknown7.6%

Age group

< 22.3%
2–111.2%
12–170.8%
18–6442.9%
65+52.9%

What is nifedipine used for

Conditions and purposes for which patients were taking nifedipine when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAbdominal Pain LowerAbortion ThreatenedAccidental ExposureAccidental Exposure To ProductAccidental OverdoseAcneAcute Coronary SyndromeAcute Kidney InjuryAcute Myocardial InfarctionAdverse EventAnal FissureAneurysmAngina Pectoris

Showing 15 of 687 indications

Nifedipine brand names and reporting trend

Nifedipine is sold under the brand name Adalat Cc.

Brand names

Adalat Cc45,186

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nifedipine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.