OpenClaim

Nicardipine Side Effects

The most commonly reported side effects of nicardipine include acute kidney injury, off label use, and foetal exposure during pregnancy, based on 5,728 FDA adverse event reports from 2004 to 2025. 3.4% of reports found the drug to be ineffective.

Nicardipine side effects

Percentages show how often each reaction appears relative to total reports for nicardipine.

1
Acute Kidney Injury4.8%273
2
Off Label Use3.8%215
3
Foetal Exposure During Pregnancy3.6%205
4
Drug Ineffective3.4%196
5
Premature Baby3.4%194
6
Maternal Exposure During Pregnancy3.3%187
7
Hypotension2.8%160
8
Hypertension2.7%157
9
Drug Interaction2.7%153
10
Pyrexia2.0%116
11
Premature Delivery1.9%110
12
Diarrhoea1.9%109
13
Exposure During Pregnancy1.9%107
14
Vomiting1.8%103
15
Low Birth Weight Baby1.8%102

These are voluntary reports and do not establish that nicardipine caused these reactions.

Report severity

95.2%Serious5,451 reports
54.1%Hospitalizations3,099 reports
13.7%Fatal786 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nicardipine drug interactions

Other drugs that appear in adverse event reports alongside nicardipine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Furosemide7.7%441
2
Labetalol-hydrochloride5.6%322
3
Hydrochlorothiazide4.9%282
4
Metformin4.8%273
5
Amoxicillin4.2%241
6
Amlodipine3.9%221
7
Ramipril3.8%220
8
Insulin3.8%218
9
Tramadol-hydrochloride3.7%211
10
Propofol3.4%197
11
Tacrolimus3.3%191
12
Dexamethasone3.3%190
13
Acetaminophen3.2%184
14
Enoxaparin-sodium3.1%175
15
Methyldopa3.0%173

Taken alongside

1
Furosemide12.9%740
2
Acetaminophen11.5%660
3
Amlodipine8.3%478
4
Insulin8.0%456
5
Aspirin7.6%435
6
Fentanyl7.0%399
7
Heparin6.9%393
8
Omeprazole6.7%381
9
Pantoprazole-sodium6.5%374
10
Potassium-chloride5.8%334
11
Propofol5.6%319
12
Midazolam5.2%297
13
Levothyroxine-sodium5.2%297
14
Atorvastatin-calcium5.0%284
15
Famotidine4.8%277

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nicardipine side effects

47.1% of nicardipine adverse event reports involve female patients and 41.9% involve male patients. The largest age group is elderly at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.1%
Male41.9%
Unknown11.0%

Age group

< 25.1%
2–113.1%
12–172.5%
18–6441.5%
65+47.9%

What is nicardipine used for

Conditions and purposes for which patients were taking nicardipine when the adverse event was reported.

Abortion ThreatenedAcute Myeloid LeukaemiaAdverse Drug ReactionAmenorrhoeaAnaemiaAnal Cancer Stage IvAngina PectorisAortic AneurysmAortic Aneurysm SyphiliticAortic DissectionAortic Valve IncompetenceArteriospasm CoronaryAtrial FibrillationAtypical Haemolytic Uraemic SyndromeAbdominal Pain Upper

Showing 15 of 256 indications

Nicardipine brand names and reporting trend

Nicardipine is sold under the brand name Cardene In 0.83% Sodium Chloride In Plastic Container.

Brand names

Cardene In 0.83% Sodium Chloride In Plastic Container46

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nicardipine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.