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Niacinamide Side Effects

The most commonly reported side effects of niacinamide include flushing, nausea, and pruritus, based on 7,328 FDA adverse event reports from 2004 to 2025.

Niacinamide side effects

Percentages show how often each reaction appears relative to total reports for niacinamide.

1
Flushing9.9%725
2
Nausea4.3%317
3
Pruritus4.0%296
4
Diarrhoea3.6%264
5
Weight Decreased3.3%242
6
Diarrhoea3.3%241
7
Nausea3.2%232
8
Fatigue2.8%207
9
Paraesthesia2.8%206
10
Feeling Hot2.8%204
11
Dyspnoea2.8%202
12
Fatigue2.7%197
13
Vomiting2.6%187
14
Weight Increased2.5%186
15
Abdominal Pain2.5%185

These are voluntary reports and do not establish that niacinamide caused these reactions.

Report severity

62.3%Serious4,562 reports
37.8%Hospitalizations2,770 reports
8.1%Fatal595 reports

Seriousness is determined by the reporter, not by OpenClaim.

Niacinamide drug interactions

Other drugs that appear in adverse event reports alongside niacinamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Niacin11.8%863
2
Teduglutide8.9%653
3
Pyridoxine6.7%489
4
Adalimumab6.6%487
5
Tyrosine3.5%259
6
Ascorbic-acid3.4%247
7
Folic-acid3.1%230
8
Warfarin3.0%218
9
Dexpanthenol3.0%218
10
Cyanocobalamin2.9%216
11
Thiamine2.9%212
12
Riboflavin2.8%208
13
Biotin2.6%194
14
Cholecalciferol2.6%190
15
Vitamin-k2.3%171

Taken alongside

1
Pyridoxine81.5%5,973
2
Ergocalciferol64.0%4,688
3
Cyanocobalamin60.0%4,399
4
Ascorbic-acid59.2%4,339
5
Folic-acid58.8%4,312
6
Vitamin-e57.6%4,221
7
Biotin57.6%4,218
8
Thiamine57.3%4,199
9
Riboflavin57.2%4,189
10
Dexpanthenol56.9%4,171
11
Vitamin-a56.3%4,122
12
Tyrosine24.7%1,809
13
Aspirin23.8%1,741
14
Acetaminophen15.2%1,115
15
Calcium12.5%913

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports niacinamide side effects

52.6% of niacinamide adverse event reports involve female patients and 42.6% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.6%
Male42.6%
Unknown4.8%

Age group

< 22.9%
2–114.1%
12–172.3%
18–6450.5%
65+40.3%

What is niacinamide used for

Conditions and purposes for which patients were taking niacinamide when the adverse event was reported.

Abdominal PainAcneAcute Graft Versus Host DiseaseAcute Lymphocytic LeukaemiaAdverse EventAlopeciaAnaemiaAnorexiaAntiinflammatory TherapyArthritisArthropathyAstheniaAtrial FibrillationAcneB-cell Lymphoma

Showing 15 of 201 indications

Niacinamide brand names and reporting trend

Niacinamide is sold under the brand name M.v.i.-12 Adult.

Brand names

M.v.i.-12 Adult979

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking niacinamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.