OpenClaim

Netupitant Side Effects

The most commonly reported side effects of netupitant include nausea, diarrhoea, and neutropenia, based on 1,892 FDA adverse event reports from 2014 to 2025.

Netupitant side effects

Percentages show how often each reaction appears relative to total reports for netupitant.

1
Nausea12.4%235
2
Diarrhoea10.0%189
3
Neutropenia8.4%159
4
Fatigue7.5%142
5
Vomiting7.1%134
6
Anaemia6.8%128
7
Dyspnoea6.7%126
8
Decreased Appetite6.6%124
9
Off Label Use6.2%118
10
Febrile Neutropenia6.2%117
11
Asthenia5.4%102
12
Pyrexia5.3%100
13
Thrombocytopenia5.2%99
14
Death5.2%99
15
Constipation5.0%94

These are voluntary reports and do not establish that netupitant caused these reactions.

Report severity

94.5%Serious1,787 reports
55.3%Hospitalizations1,047 reports
13.7%Fatal260 reports

Seriousness is determined by the reporter, not by OpenClaim.

Netupitant drug interactions

Other drugs that appear in adverse event reports alongside netupitant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Carboplatin26.0%491
2
Palonosetron-hydrochloride23.3%440
3
Fosnetupitant-chloride-hydrochloride21.8%413
4
Paclitaxel14.5%275
5
Cyclophosphamide11.1%210
6
Atezolizumab9.6%182
7
Oxaliplatin9.2%175
8
Pembrolizumab8.3%157
9
Pemetrexed8.2%156
10
Cisplatin7.9%149
11
Dexamethasone7.6%144
12
Fluorouracil6.9%131
13
Trastuzumab6.8%128
14
Doxorubicin-hydrochloride6.6%124
15
Nivolumab6.1%115

Taken alongside

1
Palonosetron-hydrochloride66.2%1,253
2
Dexamethasone52.9%1,000
3
Fosnetupitant-chloride-hydrochloride50.9%963
4
Acetaminophen15.3%289
5
Pantoprazole-sodium13.7%259
6
Pegfilgrastim13.0%246
7
Metoclopramide-hydrochloride10.9%206
8
Ondansetron10.3%195
9
Folic-acid9.9%188
10
Olanzapine8.5%161
11
Loperamide-hydrochloride7.6%144
12
Aspirin7.2%136
13
Omeprazole7.1%135
14
Levothyroxine-sodium6.8%129
15
Furosemide6.7%126

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports netupitant side effects

57.4% of netupitant adverse event reports involve female patients and 36.4% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.4%
Male36.4%
Unknown6.2%

Age group

< 20.0%
2–11<0.1%
12–170.4%
18–6455.2%
65+44.3%

What is netupitant used for

Conditions and purposes for which patients were taking netupitant when the adverse event was reported.

Anal CancerAntiemetic Supportive CareAngioimmunoblastic T-cell LymphomaAntiemetic Supportive CareBladder CancerBrain Cancer MetastaticBrain Neoplasm MalignantBreast CancerBreast Cancer FemaleBreast Cancer Stage IBronchial CarcinomaBile Duct CancerBladder CancerBreast CancerBreast Cancer Female

Showing 15 of 82 indications

Netupitant brand names and reporting trend

Netupitant is sold under the brand name Akynzeo.

Brand names

Akynzeo673

Quarterly reports (20142025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking netupitant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.