OpenClaim

Nesiritide Side Effects

The most commonly reported side effects of nesiritide include hypotension, renal failure, and injury, based on 396 FDA adverse event reports from 2004 to 2025.

Nesiritide side effects

Percentages show how often each reaction appears relative to total reports for nesiritide.

1
Hypotension22.5%89
2
Renal Failure16.7%66
3
Injury13.9%55
4
Pain13.1%52
5
Cardiac Failure Congestive12.1%48
6
Anxiety11.6%46
7
Unevaluable Event11.4%45
8
Death9.6%38
9
Emotional Distress9.1%36
10
Fear8.8%35
11
Renal Impairment8.1%32
12
Renal Injury7.8%31
13
Renal Failure Acute7.1%28
14
Anhedonia7.1%28
15
Asthenia6.8%27

These are voluntary reports and do not establish that nesiritide caused these reactions.

Report severity

81.6%Serious323 reports
40.9%Hospitalizations162 reports
29.3%Fatal116 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nesiritide drug interactions

Other drugs that appear in adverse event reports alongside nesiritide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aprotinin12.1%48
2
Digoxin5.6%22
3
Furosemide3.8%15
4
Metolazone2.8%11
5
Bumetanide2.0%8
6
Heparin2.0%8
7
Aspirin1.8%7
8
Warfarin1.5%6
9
Metoprolol1.5%6
10
Lisinopril1.5%6
11
Spironolactone1.3%5
12
Allopurinol1.3%5
13
Infliximab1.3%5
14
Insulin1.0%4
15
Isosorbide1.0%4

Taken alongside

1
Furosemide42.9%170
2
Aspirin25.3%100
3
Metoprolol19.7%78
4
Digoxin19.4%77
5
Carvedilol18.4%73
6
Warfarin17.9%71
7
Spironolactone17.2%68
8
Potassium-chloride15.2%60
9
Simvastatin13.9%55
10
Acetaminophen13.9%55
11
Insulin13.6%54
12
Amiodarone-hydrochloride13.6%54
13
Heparin13.6%54
14
Atorvastatin-calcium13.4%53
15
Lisinopril13.1%52

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nesiritide side effects

38.4% of nesiritide adverse event reports involve female patients and 52.3% involve male patients. The largest age group is elderly at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.4%
Male52.3%
Unknown9.3%

Age group

< 21.1%
2–110.4%
12–170.4%
18–6435.8%
65+62.5%

What is nesiritide used for

Conditions and purposes for which patients were taking nesiritide when the adverse event was reported.

Accidental ExposureAcute Myocardial InfarctionBlood Pressure MeasurementCardiac DisorderCardiac FailureCardiac Failure AcuteCardiac Failure CongestiveCardiac OperationCondition AggravatedCardiac FailureCardiac Failure ChronicCoronary Artery DiseaseDrug Use For Unknown IndicationDyspnoeaDrug Therapy

Showing 15 of 32 indications

Nesiritide brand names and reporting trend

Nesiritide is sold under the brand name Natrecor.

Brand names

Natrecor184

Quarterly reports (20042025)

2005201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nesiritide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.