OpenClaim

Nepafenac Side Effects

The most commonly reported side effects of nepafenac include eye pain, treatment failure, and vision blurred, based on 3,200 FDA adverse event reports from 2005 to 2025. 10.0% of reports found the drug to be ineffective.

Nepafenac side effects

Percentages show how often each reaction appears relative to total reports for nepafenac.

1
Eye Pain13.6%435
2
Drug Ineffective10.0%319
3
Treatment Failure7.2%229
4
Vision Blurred6.0%191
5
Off Label Use4.1%131
6
Visual Impairment3.7%119
7
Cataract3.5%112
8
Eye Irritation2.9%92
9
Fatigue2.9%92
10
Chronic Kidney Disease2.3%73
11
Product Quality Issue2.1%66
12
Nausea2.0%65
13
Headache2.0%64
14
Macular Oedema2.0%63
15
Ocular Hyperaemia1.8%59

These are voluntary reports and do not establish that nepafenac caused these reactions.

Report severity

44.8%Serious1,432 reports
11.8%Hospitalizations378 reports
2.3%Fatal72 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nepafenac drug interactions

Other drugs that appear in adverse event reports alongside nepafenac. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Prednisolone7.1%228
2
Dexamethasone6.8%216
3
Moxifloxacin-hydrochloride4.6%147
4
Diclofenac3.4%110
5
Difluprednate3.4%109
6
Ketorolac-tromethamine3.3%105
7
Lenalidomide3.3%105
8
Bromfenac-sodium2.3%75
9
Adalimumab2.3%73
10
Fluorometholone2.0%64
11
Potassium-chloride1.9%60
12
Omeprazole1.9%60
13
Sodium-chloride1.8%58
14
Calcium-chloride1.8%57
15
Magnesium-chloride1.8%57

Taken alongside

1
Prednisolone10.8%347
2
Moxifloxacin-hydrochloride9.3%299
3
Difluprednate8.3%265
4
Aspirin7.6%242
5
Acetaminophen7.1%226
6
Prednisone6.6%210
7
Dexamethasone6.4%206
8
Ergocalciferol6.3%203
9
Amlodipine5.6%179
10
Metoprolol5.0%160
11
Furosemide4.9%156
12
Omeprazole4.8%154
13
Fluticasone4.7%151
14
Atorvastatin-calcium4.6%147
15
Albuterol4.5%145

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nepafenac side effects

42.6% of nepafenac adverse event reports involve female patients and 29.4% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.6%
Male29.4%
Unknown28.0%

Age group

< 20.2%
2–110.7%
12–170.2%
18–6438.3%
65+60.7%

What is nepafenac used for

Conditions and purposes for which patients were taking nepafenac when the adverse event was reported.

Acanthamoeba KeratitisAnalgesic TherapyAntibiotic ProphylaxisAntiinflammatory TherapyArteritisAcanthamoeba KeratitisAcute Macular NeuroretinopathyAntiinflammatory TherapyBlindnessBack PainCataractCataract OperationCataract Operation ComplicationChorioretinopathyChoroidal Effusion

Showing 15 of 148 indications

Nepafenac brand names and reporting trend

Nepafenac is sold under the brand name Nevanac.

Brand names

Nevanac337

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nepafenac with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.