OpenClaim

Nefazodone Side Effects

The most commonly reported side effects of nefazodone include diabetes mellitus, depression, and nausea, based on 2,347 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Nefazodone side effects

Percentages show how often each reaction appears relative to total reports for nefazodone.

1
Diabetes Mellitus6.4%151
2
Depression5.8%136
3
Nausea5.2%123
4
Type 2 Diabetes Mellitus4.6%108
5
Anxiety4.5%105
6
Fatigue4.4%104
7
Drug Ineffective4.3%100
8
Insomnia4.2%98
9
Dizziness4.0%94
10
Weight Increased3.8%90
11
Headache3.5%83
12
Alanine Aminotransferase Increased3.2%76
13
Suicidal Ideation3.2%75
14
Drug Ineffective3.2%75
15
Chest Pain3.1%73

These are voluntary reports and do not establish that nefazodone caused these reactions.

Report severity

59.5%Serious1,396 reports
25.2%Hospitalizations591 reports
6.5%Fatal152 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nefazodone drug interactions

Other drugs that appear in adverse event reports alongside nefazodone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate9.7%227
2
Olanzapine5.4%126
3
Paroxetine3.6%85
4
Venlafaxine2.9%67
5
Bupropion2.8%66
6
Sertraline-hydrochloride2.6%61
7
Gabapentin2.6%60
8
Oxycodone2.4%57
9
Fluoxetine-hydrochloride2.2%51
10
Acetaminophen2.2%51
11
Duloxetine-hydrochloride2.1%49
12
Risperidone2.0%47
13
Aripiprazole1.8%43
14
Citalopram-hydrobromide1.8%42
15
Sodium-oxybate1.5%36

Taken alongside

1
Clonazepam12.1%284
2
Acetaminophen12.1%283
3
Bupropion10.7%252
4
Alprazolam10.2%239
5
Gabapentin9.9%233
6
Aspirin9.7%228
7
Levothyroxine-sodium9.5%223
8
Trazodone-hydrochloride8.5%200
9
Lorazepam8.5%199
10
Sertraline-hydrochloride7.5%175
11
Zolpidem-tartrate7.3%172
12
Venlafaxine7.2%170
13
Omeprazole6.6%154
14
Lisinopril6.5%153
15
Hydrocodone6.4%151

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nefazodone side effects

60.2% of nefazodone adverse event reports involve female patients and 36.4% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.2%
Male36.4%
Unknown3.4%

Age group

< 20.1%
2–110.5%
12–171.3%
18–6480.6%
65+17.4%

What is nefazodone used for

Conditions and purposes for which patients were taking nefazodone when the adverse event was reported.

Affective DisorderAgoraphobiaAngerAntidepressant TherapyAnxietyAnxiety DisorderAsthmaAutism Spectrum DisorderAutonomic Nervous System ImbalanceAlopeciaAntipsychotic TherapyAnxietyBereavement ReactionBipolar DisorderBipolar I Disorder

Showing 15 of 69 indications

Nefazodone brand names and reporting trend

Nefazodone is sold under the brand name Nefazodone Hydrochloride.

Brand names

Nefazodone Hydrochloride2

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nefazodone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.