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Nedosiran Side Effects

The most commonly reported side effects of nedosiran include urine oxalate increased, renal transplant, and off label use, based on 16 FDA adverse event reports from 2017 to 2025. 6.3% of reports found the drug to be ineffective.

Nedosiran side effects

Percentages show how often each reaction appears relative to total reports for nedosiran.

1
Urine Oxalate Increased25.0%4
2
Renal Transplant18.8%3
3
Off Label Use12.5%2
4
Pulmonary Oedema12.5%2
5
Renal Impairment12.5%2
6
Rash12.5%2
7
Inappropriate Schedule Of Product Administration12.5%2
8
Urinary Tract Infection6.3%1
9
Dyspnoea6.3%1
10
Asthenia6.3%1
11
Fall6.3%1
12
Chest Injury6.3%1
13
Pleural Effusion6.3%1
14
Sepsis6.3%1
15
Injection Site Atrophy6.3%1

These are voluntary reports and do not establish that nedosiran caused these reactions.

Report severity

75.0%Serious12 reports
25.0%Hospitalizations4 reports
12.5%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nedosiran drug interactions

Other drugs that appear in adverse event reports alongside nedosiran. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lumasiran-sodium50.0%8
2
Apixaban6.3%1

Taken alongside

1
Pregabalin6.3%1
2
Furosemide6.3%1
3
Technetium-tc-99m-albumin-aggregated-kit6.3%1
4
Cephalexin6.3%1
5
Codeine6.3%1
6
Spironolactone6.3%1
7
Atorvastatin-calcium6.3%1
8
Pseudoephedrine6.3%1
9
Triprolidine-hydrochloride6.3%1
10
Amiodarone-hydrochloride6.3%1
11
Quetiapine-fumarate6.3%1
12
Acetaminophen6.3%1
13
Tramadol-hydrochloride6.3%1
14
Etomidate6.3%1
15
Tigecycline6.3%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nedosiran side effects

37.5% of nedosiran adverse event reports involve female patients and 12.5% involve male patients. The largest age group is elderly at 43%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.5%
Male12.5%
Unknown50.0%

Age group

< 214.3%
2–1128.6%
12–170.0%
18–6414.3%
65+42.9%

What is nedosiran used for

Conditions and purposes for which patients were taking nedosiran when the adverse event was reported.

Primary HyperoxaluriaProduct Used For Unknown IndicationViral Upper Respiratory Tract Infection

Nedosiran brand names and reporting trend

Nedosiran is sold under the brand name Rivfloza.

Brand names

Rivfloza12

Quarterly reports (20172025)

20172025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nedosiran with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.