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Necitumumab Side Effects

The most commonly reported side effects of necitumumab include platelet count decreased, malignant neoplasm progression, and hypomagnesaemia, based on 565 FDA adverse event reports from 2010 to 2025.

Necitumumab side effects

Percentages show how often each reaction appears relative to total reports for necitumumab.

1
Platelet Count Decreased13.5%76
2
Malignant Neoplasm Progression11.0%62
3
Hypomagnesaemia9.9%56
4
Rash9.7%55
5
Neutrophil Count Decreased8.8%50
6
Dermatitis Acneiform8.3%47
7
Febrile Neutropenia6.7%38
8
Neutropenia5.8%33
9
Decreased Appetite5.5%31
10
Pneumonia4.6%26
11
Nausea4.1%23
12
Anaemia3.9%22
13
Death3.7%21
14
White Blood Cell Count Decreased3.7%21
15
Diarrhoea3.2%18

These are voluntary reports and do not establish that necitumumab caused these reactions.

Report severity

94.0%Serious531 reports
49.9%Hospitalizations282 reports
22.3%Fatal126 reports

Seriousness is determined by the reporter, not by OpenClaim.

Necitumumab drug interactions

Other drugs that appear in adverse event reports alongside necitumumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cisplatin60.7%343
2
Gemcitabine54.2%306
3
Pemetrexed11.5%65
4
Carboplatin3.5%20
5
Paclitaxel3.4%19
6
Pembrolizumab2.5%14
7
Trastuzumab1.6%9
8
Osimertinib-mesylate1.4%8
9
Ramucirumab0.9%5
10
Afatinib0.7%4
11
Nivolumab0.7%4
12
Diphenhydramine0.5%3
13
Ipilimumab0.5%3
14
Dexamethasone0.4%2
15
Aprepitant0.4%2

Taken alongside

1
Cisplatin17.9%101
2
Gemcitabine15.2%86
3
Magnesium-sulfate9.6%54
4
Dexamethasone8.5%48
5
Aspirin4.2%24
6
Furosemide4.1%23
7
Acetaminophen4.1%23
8
Tiotropium-bromide4.1%23
9
Ondansetron4.1%23
10
Ipratropium-bromide3.9%22
11
Omeprazole3.7%21
12
Folic-acid3.5%20
13
Albuterol3.2%18
14
Palonosetron-hydrochloride3.2%18
15
Aprepitant2.8%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports necitumumab side effects

17.9% of necitumumab adverse event reports involve female patients and 70.1% involve male patients. The largest age group is elderly at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female17.9%
Male70.1%
Unknown12.0%

Age group

< 20.5%
2–110.0%
12–170.0%
18–6433.9%
65+65.6%

What is necitumumab used for

Conditions and purposes for which patients were taking necitumumab when the adverse event was reported.

Breast Cancer MetastaticChemotherapyColorectal Cancer MetastaticEgfr Gene MutationGallbladder Cancer MetastaticHead And Neck CancerHepatic Cancer MetastaticLung Cancer MetastaticLung Carcinoma Cell Type Unspecified Stage ILung Carcinoma Cell Type Unspecified Stage IvLung Neoplasm MalignantLung Squamous Cell Carcinoma MetastaticLung Squamous Cell Carcinoma RecurrentLung Squamous Cell Carcinoma Stage IiLung Squamous Cell Carcinoma Stage Iii

Showing 15 of 44 indications

Necitumumab brand names and reporting trend

Necitumumab is sold under the brand name Portrazza.

Brand names

Portrazza534

Quarterly reports (20102025)

201020122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking necitumumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.