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Nateglinide Side Effects

The most commonly reported side effects of nateglinide include blood glucose increased, nausea, and weight decreased, based on 3,574 FDA adverse event reports from 2004 to 2025. 2.6% of reports found the drug to be ineffective.

Nateglinide side effects

Percentages show how often each reaction appears relative to total reports for nateglinide.

1
Blood Glucose Increased10.4%373
2
Nausea7.3%261
3
Weight Decreased5.9%210
4
Dizziness3.6%130
5
Vomiting3.6%129
6
Blood Glucose Increased3.3%118
7
Decreased Appetite3.2%116
8
Blood Glucose Decreased3.1%110
9
Asthenia3.1%110
10
Dyspnoea2.8%101
11
Diarrhoea2.8%100
12
Diarrhoea2.8%100
13
Myocardial Infarction2.6%93
14
Drug Ineffective2.6%93
15
Nausea2.5%90

These are voluntary reports and do not establish that nateglinide caused these reactions.

Report severity

62.5%Serious2,233 reports
35.1%Hospitalizations1,256 reports
9.5%Fatal338 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nateglinide drug interactions

Other drugs that appear in adverse event reports alongside nateglinide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Exenatide-synthetic16.7%596
2
Metformin7.4%263
3
Rosiglitazone-maleate5.1%182
4
Pioglitazone-hydrochloride5.0%180
5
Insulin4.3%154
6
Valsartan2.7%96
7
Lenalidomide2.5%89
8
Adalimumab2.0%73
9
Sitagliptin2.0%72
10
Omeprazole2.0%70
11
Esomeprazole1.8%66
12
Lansoprazole1.3%48
13
Pantoprazole-sodium1.2%44
14
Patiromer-sorbitex-calcium1.1%41
15
Rosuvastatin1.1%38

Taken alongside

1
Metformin33.9%1,210
2
Insulin22.4%800
3
Aspirin20.0%714
4
Atorvastatin-calcium14.8%528
5
Furosemide14.3%511
6
Amlodipine13.0%464
7
Levothyroxine-sodium12.0%430
8
Acetaminophen11.6%415
9
Metoprolol10.4%370
10
Simvastatin9.7%346
11
Lisinopril9.5%340
12
Pioglitazone-hydrochloride9.1%324
13
Ergocalciferol9.0%321
14
Gabapentin8.1%290
15
Sitagliptin7.8%279

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nateglinide side effects

51.5% of nateglinide adverse event reports involve female patients and 43.6% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.5%
Male43.6%
Unknown4.9%

Age group

< 2<0.1%
2–110.0%
12–170.7%
18–6442.2%
65+57.1%

What is nateglinide used for

Conditions and purposes for which patients were taking nateglinide when the adverse event was reported.

Acute Kidney InjuryBlood Cholesterol IncreasedBlood GlucoseBlood Glucose AbnormalBlood Glucose DecreasedBlood Glucose FluctuationBlood Glucose IncreasedBlood Sugar IncreasedBlood TriglyceridesBlood Glucose IncreasedCardiovascular DisorderCerebral InfarctionCystic Fibrosis Related DiabetesDiabetesDiabetes Mellitus

Showing 15 of 36 indications

Nateglinide brand names and reporting trend

Nateglinide is sold under the brand name Nateglinide.

Brand names

Nateglinide1,404

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nateglinide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.