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Natamycin Side Effects

The most commonly reported side effects of natamycin include condition aggravated, off label use, and persistent genital arousal disorder, based on 381 FDA adverse event reports from 2008 to 2025. 25.7% of reports found the drug to be ineffective.

Natamycin side effects

Percentages show how often each reaction appears relative to total reports for natamycin.

1
Drug Ineffective25.7%98
2
Condition Aggravated19.2%73
3
Off Label Use15.7%60
4
Persistent Genital Arousal Disorder10.2%39
5
Eye Pain10.0%38
6
Somnolence10.0%38
7
Vomiting9.4%36
8
Abdominal Distension9.4%36
9
Abdominal Pain9.2%35
10
Nausea8.9%34
11
Appendicolith8.9%34
12
Appendicitis8.9%34
13
Ascites8.9%34
14
Ventricular Fibrillation8.7%33
15
Dry Mouth8.7%33

These are voluntary reports and do not establish that natamycin caused these reactions.

Report severity

73.8%Serious281 reports
34.4%Hospitalizations131 reports
18.4%Fatal70 reports

Seriousness is determined by the reporter, not by OpenClaim.

Natamycin drug interactions

Other drugs that appear in adverse event reports alongside natamycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen24.7%94
2
Voriconazole18.9%72
3
Furazolidone17.1%65
4
Betamethasone16.8%64
5
Warfarin16.3%62
6
Metronidazole16.0%61
7
Allopurinol16.0%61
8
Sodium-citrate16.0%61
9
Fluticasone16.0%61
10
Ceftriaxone-sodium16.0%61
11
Dextrose16.0%61
12
Vilanterol-trifenatate16.0%61
13
Dalteparin-sodium16.0%61
14
Phytonadione16.0%61
15
Insulin16.0%61

Taken alongside

1
Estropipate12.6%48
2
Ergocalciferol11.8%45
3
Amlodipine11.5%44
4
Voriconazole10.2%39
5
Moxifloxacin-hydrochloride10.0%38
6
Riboflavin8.1%31
7
Vancomycin7.3%28
8
Amphotericin-b6.6%25
9
Ascorbic-acid6.6%25
10
Cholecalciferol6.0%23
11
Prednisolone5.8%22
12
Beta-carotene5.5%21
13
Warfarin5.0%19
14
Hydromorphone-hydrochloride5.0%19
15
Fluconazole4.2%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports natamycin side effects

47.8% of natamycin adverse event reports involve female patients and 43.8% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.8%
Male43.8%
Unknown8.4%

Age group

< 20.7%
2–111.0%
12–170.0%
18–6460.7%
65+37.6%

What is natamycin used for

Conditions and purposes for which patients were taking natamycin when the adverse event was reported.

Antibiotic TherapyAntifungal ProphylaxisAntifungal TreatmentAspergillus InfectionAntibiotic TherapyBacterial InfectionCandida InfectionConjunctivitis FungalDermatitis AtopicDrug Use For Unknown IndicationEndophthalmitisExserohilum InfectionEye InfectionEye Infection FungalEye Pain

Showing 15 of 58 indications

Natamycin brand names and reporting trend

Natamycin is sold under the brand name Natacyn.

Brand names

Natacyn334

Quarterly reports (20082025)

200820202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking natamycin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.