OpenClaim

Naloxegol Side Effects

The most commonly reported side effects of naloxegol include constipation, diarrhoea, and pain, based on 4,146 FDA adverse event reports from 2015 to 2025. 9.2% of reports found the drug to be ineffective.

Naloxegol side effects

Percentages show how often each reaction appears relative to total reports for naloxegol.

1
Constipation9.9%411
2
Diarrhoea9.8%405
3
Drug Ineffective9.2%380
4
Pain9.0%373
5
Nausea8.5%354
6
Off Label Use6.8%282
7
Abdominal Pain6.4%266
8
Abdominal Pain Upper5.6%233
9
Intentional Product Misuse5.4%225
10
Vomiting5.4%223
11
Fatigue4.8%197
12
Death4.7%195
13
Hyperhidrosis4.7%194
14
Headache4.5%186
15
Malaise4.1%172

These are voluntary reports and do not establish that naloxegol caused these reactions.

Report severity

50.6%Serious2,097 reports
25.4%Hospitalizations1,055 reports
7.9%Fatal328 reports

Seriousness is determined by the reporter, not by OpenClaim.

Naloxegol drug interactions

Other drugs that appear in adverse event reports alongside naloxegol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate3.1%129
2
Lenalidomide2.8%115
3
Omeprazole2.7%112
4
Oxycodone2.4%99
5
Esomeprazole2.2%90
6
Pregabalin2.0%83
7
Pantoprazole-sodium2.0%82
8
Fentanyl1.8%76
9
Acetaminophen1.8%74
10
Pomalidomide1.3%53
11
Ciprofloxacin1.3%53
12
Lisinopril1.3%52
13
Morphine-sulfate1.2%50
14
Enoxaparin-sodium1.2%50
15
Etanercept1.2%48

Taken alongside

1
Oxycodone28.0%1,159
2
Acetaminophen23.5%974
3
Gabapentin15.4%640
4
Ondansetron12.9%534
5
Ergocalciferol12.4%516
6
Levothyroxine-sodium11.3%468
7
Pantoprazole-sodium11.1%461
8
Omeprazole10.8%447
9
Aspirin10.1%420
10
Albuterol9.8%407
11
Furosemide9.6%398
12
Fentanyl9.4%389
13
Pregabalin9.1%378
14
Hydrocodone9.0%374
15
Atorvastatin-calcium9.0%373

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports naloxegol side effects

53.5% of naloxegol adverse event reports involve female patients and 37.5% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.5%
Male37.5%
Unknown9.0%

Age group

< 20.2%
2–110.2%
12–170.3%
18–6454.3%
65+45.1%

What is naloxegol used for

Conditions and purposes for which patients were taking naloxegol when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbnormal FaecesAcute Lymphocytic LeukaemiaAdjuvant TherapyAtrioventricular BlockAbdominal DiscomfortAbnormal FaecesAnalgesic Intervention Supportive TherapyAnxietyBack DisorderBack PainBowel Movement IrregularityBack PainBowel Movement Irregularity

Showing 15 of 98 indications

Naloxegol brand names and reporting trend

Naloxegol is sold under brand names including Movantik, Naloxegol.

Brand names

Movantik441
Naloxegol376

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking naloxegol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.