The most commonly reported side effects of naldemedine include diarrhoea, nausea, and constipation, based on 1,659 FDA adverse event reports from 2014 to 2025. 6.7% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for naldemedine.
These are voluntary reports and do not establish that naldemedine caused these reactions.
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Other drugs that appear in adverse event reports alongside naldemedine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
41.6% of naldemedine adverse event reports involve female patients and 48.8% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking naldemedine when the adverse event was reported.
Showing 15 of 50 indications
Naldemedine is sold under the brand name Symproic.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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