OpenClaim

Naftifine Side Effects

The most commonly reported side effects of naftifine include pruritus, skin exfoliation, and rash, based on 426 FDA adverse event reports from 2005 to 2025. 6.6% of reports found the drug to be ineffective.

Naftifine side effects

Percentages show how often each reaction appears relative to total reports for naftifine.

1
Pruritus8.0%34
2
Skin Exfoliation7.0%30
3
Rash6.6%28
4
Drug Ineffective6.6%28
5
Blister6.6%28
6
Hypersensitivity6.3%27
7
Diarrhoea6.1%26
8
Chronic Kidney Disease5.9%25
9
Off Label Use5.6%24
10
Erythema4.9%21
11
Renal Failure4.7%20
12
Pain4.5%19
13
Headache4.0%17
14
Fatigue3.5%15
15
Acute Kidney Injury3.5%15

These are voluntary reports and do not establish that naftifine caused these reactions.

Report severity

52.3%Serious223 reports
23.0%Hospitalizations98 reports
4.2%Fatal18 reports

Seriousness is determined by the reporter, not by OpenClaim.

Naftifine drug interactions

Other drugs that appear in adverse event reports alongside naftifine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide8.0%34
2
Sodium-oxybate6.8%29
3
Omeprazole6.1%26
4
Esomeprazole4.5%19
5
Lansoprazole3.3%14
6
Pantoprazole-sodium2.6%11
7
Adalimumab2.3%10
8
Apremilast2.3%10
9
Dupilumab2.3%10
10
Tacrolimus2.1%9
11
Ibrutinib2.1%9
12
Methylprednisolone1.6%7
13
Mycophenolate1.6%7
14
Dexlansoprazole1.4%6
15
Exenatide-synthetic1.2%5

Taken alongside

1
Acetaminophen20.9%89
2
Aspirin20.9%89
3
Ergocalciferol20.4%87
4
Amlodipine15.5%66
5
Fluticasone14.8%63
6
Albuterol14.3%61
7
Atorvastatin-calcium12.9%55
8
Gabapentin12.4%53
9
Levothyroxine-sodium12.0%51
10
Triamcinolone11.7%50
11
Metformin11.5%49
12
Omeprazole11.5%49
13
Ibuprofen11.5%49
14
Lisinopril10.8%46
15
Tramadol-hydrochloride10.8%46

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports naftifine side effects

45.5% of naftifine adverse event reports involve female patients and 48.1% involve male patients. The largest age group is adult at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.5%
Male48.1%
Unknown6.3%

Age group

< 20.3%
2–112.1%
12–172.4%
18–6447.8%
65+47.4%

What is naftifine used for

Conditions and purposes for which patients were taking naftifine when the adverse event was reported.

Antifungal TreatmentArthritisAlopecia ScarringBlisterBody TineaBurning SensationCellulitisDrug Use For Unknown IndicationDry SkinDermatophytosisEczemaFungal InfectionFungal Skin InfectionFungal Foot InfectionFungal Infection

Showing 15 of 38 indications

Naftifine brand names and reporting trend

Naftifine is sold under the brand name Naftin.

Brand names

Naftin7

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking naftifine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.