OpenClaim

Nafarelin Side Effects

The most commonly reported side effects of nafarelin include ovarian hyperstimulation syndrome, ascites, and dyspnoea, based on 343 FDA adverse event reports from 2004 to 2025. 2.3% of reports found the drug to be ineffective.

Nafarelin side effects

Percentages show how often each reaction appears relative to total reports for nafarelin.

1
Ovarian Hyperstimulation Syndrome16.9%58
2
Ascites5.5%19
3
Dyspnoea5.5%19
4
Off Label Use4.7%16
5
Condition Aggravated3.8%13
6
Diarrhoea3.8%13
7
Nausea3.5%12
8
Abdominal Pain Lower3.5%12
9
Abdominal Pain3.2%11
10
Headache2.9%10
11
Pain2.9%10
12
Endometriosis2.6%9
13
Depressed Mood2.6%9
14
Fatigue2.6%9
15
Depression2.6%9

These are voluntary reports and do not establish that nafarelin caused these reactions.

Report severity

85.4%Serious293 reports
39.7%Hospitalizations136 reports
3.8%Fatal13 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nafarelin drug interactions

Other drugs that appear in adverse event reports alongside nafarelin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Menotropins-fsh11.1%38
2
Progesterone8.5%29
3
Follitropin-alfa-beta8.2%28
4
Choriogonadotropin-alfa7.0%24
5
Gonadotropin-chorionic4.4%15
6
Clarithromycin2.3%8
7
Leuprolide1.7%6
8
Ganirelix-acetate1.7%6
9
Triptorelin-pamoate1.7%6
10
Meperidine-hydrochloride1.2%4
11
Estradiol1.2%4
12
Elagolix1.2%4
13
Vincristine-sulfate0.9%3
14
Doxorubicin-hydrochloride0.9%3
15
Ifosfamide0.9%3

Taken alongside

1
Acetaminophen4.7%16
2
Tramadol-hydrochloride3.2%11
3
Gabapentin2.6%9
4
Fentanyl2.6%9
5
Ketamine-hydrochloride2.3%8
6
Folic-acid2.0%7
7
Quetiapine-fumarate1.7%6
8
Levothyroxine-sodium1.7%6
9
Metformin1.7%6
10
Menotropins-fsh1.5%5
11
Ibuprofen1.5%5
12
Follitropin-alfa-beta1.2%4
13
Warfarin1.2%4
14
Cetirizine-hydrochloride1.2%4
15
Oxycodone1.2%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nafarelin side effects

91.0% of nafarelin adverse event reports involve female patients and 1.2% involve male patients. The largest age group is adult at 99%. These figures reflect who reports side effects, not underlying risk.

Sex

Female91.0%
Male1.2%
Unknown7.9%

Age group

< 20.0%
2–110.4%
12–170.0%
18–6498.8%
65+0.8%

What is nafarelin used for

Conditions and purposes for which patients were taking nafarelin when the adverse event was reported.

AdenomyosisArtificial Insemination By PartnerArtificial MenopauseAssisted FertilisationAssisted Reproductive TechnologyAdenomyosisArtificial MenopauseAssisted FertilisationAssisted Reproductive TechnologyBreast CancerControlled Ovarian StimulationCystDrug Use For Unknown IndicationDysfunctional Uterine BleedingDysmenorrhoea

Showing 15 of 52 indications

Nafarelin brand names and reporting trend

Nafarelin is sold under the brand name Synarel.

Brand names

Synarel74

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nafarelin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.