OpenClaim

Nabumetone Side Effects

The most commonly reported side effects of nabumetone include pain, fatigue, and nausea, based on 9,023 FDA adverse event reports from 2004 to 2025. 5.6% of reports found the drug to be ineffective.

Nabumetone side effects

Percentages show how often each reaction appears relative to total reports for nabumetone.

1
Drug Ineffective5.6%503
2
Pain5.3%474
3
Fatigue4.1%373
4
Nausea3.7%338
5
Headache3.7%336
6
Arthralgia3.7%333
7
Drug Hypersensitivity3.3%294
8
Chronic Kidney Disease3.0%268
9
Diarrhoea2.8%254
10
Pain In Extremity2.7%244
11
Dizziness2.6%238
12
Pain2.6%231
13
Drug Ineffective2.5%227
14
Nausea2.5%223
15
Acute Kidney Injury2.5%223

These are voluntary reports and do not establish that nabumetone caused these reactions.

Report severity

53.3%Serious4,807 reports
24.0%Hospitalizations2,166 reports
5.4%Fatal491 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nabumetone drug interactions

Other drugs that appear in adverse event reports alongside nabumetone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab13.7%1,232
2
Etanercept6.7%605
3
Sodium-oxybate4.2%379
4
Omeprazole3.0%274
5
Esomeprazole3.0%272
6
Acetaminophen2.6%238
7
Lenalidomide2.3%210
8
Ibuprofen2.3%204
9
Pregabalin2.2%199
10
Apremilast2.2%199
11
Tofacitinib2.1%189
12
Pantoprazole-sodium2.1%187
13
Gabapentin2.0%176
14
Lansoprazole1.9%169
15
Naproxen1.8%166

Taken alongside

1
Acetaminophen22.6%2,042
2
Gabapentin16.5%1,489
3
Aspirin15.4%1,390
4
Levothyroxine-sodium15.4%1,390
5
Ergocalciferol15.4%1,389
6
Omeprazole14.9%1,345
7
Methotrexate14.6%1,320
8
Folic-acid14.5%1,312
9
Prednisone13.8%1,247
10
Hydrocodone12.6%1,135
11
Albuterol12.2%1,102
12
Tramadol-hydrochloride11.7%1,054
13
Lisinopril11.3%1,024
14
Fluticasone10.8%971
15
Atorvastatin-calcium10.3%932

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nabumetone side effects

72.4% of nabumetone adverse event reports involve female patients and 23.7% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.4%
Male23.7%
Unknown3.9%

Age group

< 2<0.1%
2–110.3%
12–170.8%
18–6468.5%
65+30.3%

What is nabumetone used for

Conditions and purposes for which patients were taking nabumetone when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAbdominal Pain UpperAdjuvant TherapyAllergy TestAmnesiaAnalgesic Intervention Supportive TherapyAnalgesic TherapyAnkylosing SpondylitisAntiallergic TherapyAntiinflammatory TherapyArthralgiaArthritisArthropathyAutoimmune Disorder

Showing 15 of 218 indications

Nabumetone brand names and reporting trend

Nabumetone is sold under the brand name Nabumetone.

Brand names

Nabumetone6,752

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nabumetone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.