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Motixafortide Side Effects

The most commonly reported side effects of motixafortide include injection site pain, pruritus, and urticaria, based on 92 FDA adverse event reports from 2009 to 2025.

Motixafortide side effects

Percentages show how often each reaction appears relative to total reports for motixafortide.

1
Injection Site Pain35.9%33
2
Pruritus23.9%22
3
Urticaria19.6%18
4
Flushing17.4%16
5
Rash13.0%12
6
Injection Site Erythema9.8%9
7
Paraesthesia9.8%9
8
Injection Site Reaction8.7%8
9
Injection Site Pruritus7.6%7
10
Discomfort6.5%6
11
Nausea5.4%5
12
Erythema5.4%5
13
Adverse Drug Reaction5.4%5
14
Vomiting4.3%4
15
Pain4.3%4

These are voluntary reports and do not establish that motixafortide caused these reactions.

Report severity

16.3%Serious15 reports
7.6%Hospitalizations7 reports
3.3%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Motixafortide drug interactions

Other drugs that appear in adverse event reports alongside motixafortide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rivastigmine2.2%2
2
Ibuprofen2.2%2
3
Hydrochlorothiazide2.2%2
4
Enalapril-maleate2.2%2
5
Filgrastim2.2%2
6
Pregabalin1.1%1
7
Memantine-hydrochloride1.1%1
8
Cemiplimab-rwlc1.1%1
9
Gemcitabine1.1%1
10
Paclitaxel1.1%1
11
Voxelotor1.1%1

Taken alongside

1
Diphenhydramine43.5%40
2
Famotidine42.4%39
3
Montelukast-sodium41.3%38
4
Acetaminophen40.2%37
5
Dexamethasone27.2%25
6
Methylprednisolone7.6%7
7
Hydrocortisone6.5%6
8
Loratadine5.4%5
9
Lidocaine4.3%4
10
Prilocaine3.3%3
11
Plerixafor3.3%3
12
Aspirin2.2%2
13
Omeprazole2.2%2
14
Sodium-chloride2.2%2
15
Menthol2.2%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports motixafortide side effects

18.5% of motixafortide adverse event reports involve female patients and 14.1% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female18.5%
Male14.1%
Unknown67.4%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6471.4%
65+28.6%

What is motixafortide used for

Conditions and purposes for which patients were taking motixafortide when the adverse event was reported.

ApheresisAutologous Haematopoietic Stem Cell TransplantHaematopoietic Stem Cell MobilisationOtitis ExternaPancreatic Carcinoma MetastaticPlasma Cell MyelomaProduct Used For Unknown IndicationStem Cell Transplant

Motixafortide brand names and reporting trend

Motixafortide is sold under the brand name Aphexda.

Brand names

Aphexda11

Quarterly reports (20092025)

20092025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking motixafortide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.