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Mosunetuzumab Side Effects

The most commonly reported side effects of mosunetuzumab include cytokine release syndrome, disease progression, and neutropenia, based on 784 FDA adverse event reports from 2014 to 2025.

Mosunetuzumab side effects

Percentages show how often each reaction appears relative to total reports for mosunetuzumab.

1
Cytokine Release Syndrome21.0%165
2
Disease Progression13.9%109
3
Neutropenia9.6%75
4
Covid-198.2%64
5
Off Label Use7.3%57
6
Pyrexia7.0%55
7
Death6.0%47
8
Malignant Neoplasm Progression5.7%45
9
Pneumonia5.4%42
10
Covid-19 Pneumonia4.8%38
11
Neurological Symptom4.0%31
12
Disorientation4.0%31
13
Vasogenic Cerebral Oedema4.0%31
14
Diffuse Large B-cell Lymphoma Recurrent3.6%28
15
Therapy Partial Responder3.6%28

These are voluntary reports and do not establish that mosunetuzumab caused these reactions.

Report severity

84.9%Serious666 reports
50.0%Hospitalizations392 reports
15.3%Fatal120 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mosunetuzumab drug interactions

Other drugs that appear in adverse event reports alongside mosunetuzumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Polatuzumab-vedotin-piiq22.6%177
2
Rituximab22.1%173
3
Lenalidomide20.9%164
4
Doxorubicin-hydrochloride18.5%145
5
Cyclophosphamide18.4%144
6
Prednisone18.1%142
7
Vincristine-sulfate14.9%117
8
Bendamustine-hydrochloride12.0%94
9
Dexamethasone9.9%78
10
Cytarabine9.6%75
11
Obinutuzumab7.7%60
12
Tocilizumab7.4%58
13
Cisplatin5.4%42
14
Epirubicin-hydrochloride4.8%38
15
Ibrutinib4.0%31

Taken alongside

1
Acetaminophen30.0%235
2
Dexamethasone27.7%217
3
Acyclovir24.2%190
4
Allopurinol21.6%169
5
Diphenhydramine16.8%132
6
Omeprazole11.1%87
7
Ondansetron10.7%84
8
Aspirin10.6%83
9
Sulfamethoxazole10.3%81
10
Trimethoprim9.9%78
11
Sodium-chloride9.9%78
12
Enoxaparin-sodium9.2%72
13
Pantoprazole-sodium9.1%71
14
Potassium-chloride8.4%66
15
Atorvastatin-calcium7.3%57

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mosunetuzumab side effects

40.2% of mosunetuzumab adverse event reports involve female patients and 42.7% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.2%
Male42.7%
Unknown17.1%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6443.5%
65+56.5%

What is mosunetuzumab used for

Conditions and purposes for which patients were taking mosunetuzumab when the adverse event was reported.

B-cell LymphomaB-cell LymphomaB-cell Lymphoma RefractoryChronic Lymphocytic LeukaemiaCentral Nervous System LymphomaChronic Lymphocytic LeukaemiaDiffuse Large B-cell LymphomaDiffuse Large B-cell LymphomaDiffuse Large B-cell Lymphoma RefractoryDiffuse Large B-cell Lymphoma Stage IvFollicular LymphomaFollicular LymphomaFollicular Lymphoma RecurrentFollicular Lymphoma RefractoryFollicular Lymphoma Stage Ii

Showing 15 of 35 indications

Mosunetuzumab brand names and reporting trend

Mosunetuzumab is sold under the brand name Lunsumio.

Brand names

Lunsumio763

Quarterly reports (20142025)

2014202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mosunetuzumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.