OpenClaim

Mobocertinib Side Effects

The most commonly reported side effects of mobocertinib include diarrhoea, death, and rash, based on 731 FDA adverse event reports from 2004 to 2025. 4.5% of reports found the drug to be ineffective.

Mobocertinib side effects

Percentages show how often each reaction appears relative to total reports for mobocertinib.

1
Diarrhoea42.7%312
2
Death22.4%164
3
Rash14.8%108
4
Non-small Cell Lung Cancer13.5%99
5
Nausea11.9%87
6
Decreased Appetite10.9%80
7
Vomiting10.4%76
8
Lung Neoplasm Malignant10.3%75
9
Fatigue9.3%68
10
Asthenia7.7%56
11
Weight Decreased7.4%54
12
Dry Skin7.1%52
13
Stomatitis6.2%45
14
Pneumonia6.0%44
15
Product Dose Omission Issue5.7%42

These are voluntary reports and do not establish that mobocertinib caused these reactions.

Report severity

92.1%Serious673 reports
31.1%Hospitalizations227 reports
44.6%Fatal326 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mobocertinib drug interactions

Other drugs that appear in adverse event reports alongside mobocertinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Carboplatin1.6%12
2
Pantoprazole-sodium1.6%12
3
Pemetrexed1.5%11
4
Loperamide-hydrochloride1.2%9
5
Bevacizumab1.1%8
6
Paclitaxel1.0%7
7
Atezolizumab1.0%7
8
Afatinib0.7%5
9
Denosumab0.4%3
10
Cisplatin0.4%3
11
Amivantamab0.4%3
12
Hydrocortisone0.3%2
13
Docetaxel0.3%2
14
Apomorphine-hydrochloride0.3%2
15
Dihydrocodeine-bitartrate0.3%2

Taken alongside

1
Loperamide-hydrochloride13.1%96
2
Acetaminophen7.9%58
3
Ondansetron7.5%55
4
Folic-acid6.6%48
5
Dexamethasone6.4%47
6
Atorvastatin-calcium5.7%42
7
Pantoprazole-sodium5.5%40
8
Amlodipine5.3%39
9
Ergocalciferol5.3%39
10
Metoprolol5.2%38
11
Omeprazole5.1%37
12
Prochlorperazine5.1%37
13
Levothyroxine-sodium4.9%36
14
Apixaban4.8%35
15
Oxycodone4.8%35

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mobocertinib side effects

52.5% of mobocertinib adverse event reports involve female patients and 30.1% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.5%
Male30.1%
Unknown17.4%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6448.9%
65+51.1%

What is mobocertinib used for

Conditions and purposes for which patients were taking mobocertinib when the adverse event was reported.

AdenocarcinomaBone CancerBone Cancer MetastaticBone NeoplasmBrain NeoplasmBrain Neoplasm MalignantBreast CancerBreast Cancer FemaleBronchial CarcinomaBronchial NeoplasmColon CancerDupuytren^s ContractureEgfr Gene MutationGene MutationGout

Showing 15 of 50 indications

Mobocertinib brand names and reporting trend

Mobocertinib is sold under the brand name Exkivity.

Brand names

Exkivity1,156

Quarterly reports (20042025)

20042025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mobocertinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.