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Mirdametinib Side Effects

The most commonly reported side effects of mirdametinib include rash, nausea, and fatigue, based on 68 FDA adverse event reports from 2014 to 2025.

Mirdametinib side effects

Percentages show how often each reaction appears relative to total reports for mirdametinib.

1
Rash32.4%22
2
Nausea20.6%14
3
Fatigue17.6%12
4
Pain16.2%11
5
Acne14.7%10
6
Alopecia11.8%8
7
Gastrointestinal Disorder10.3%7
8
Diarrhoea8.8%6
9
Dehydration8.8%6
10
Constipation7.4%5
11
Dermatitis Acneiform7.4%5
12
Abdominal Discomfort7.4%5
13
Pruritus7.4%5
14
Vomiting5.9%4
15
Abdominal Pain Upper4.4%3

These are voluntary reports and do not establish that mirdametinib caused these reactions.

Report severity

20.6%Serious14 reports
5.9%Hospitalizations4 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mirdametinib drug interactions

Other drugs that appear in adverse event reports alongside mirdametinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Doxycycline4.4%3
2
Tamoxifen-citrate2.9%2
3
Selumetinib2.9%2
4
Loperamide-hydrochloride2.9%2
5
Minocycline-hydrochloride2.9%2
6
Escitalopram-oxalate1.5%1
7
Empagliflozin1.5%1
8
Insulin1.5%1
9
Estropipate1.5%1
10
Olaparib1.5%1

Taken alongside

1
Doxycycline4.4%3
2
Ondansetron4.4%3
3
Trametinib2.9%2
4
Letrozole2.9%2
5
Aspirin2.9%2
6
Gabapentin2.9%2
7
Carbamazepine1.5%1
8
Carboplatin1.5%1
9
Paclitaxel1.5%1
10
Gemcitabine1.5%1
11
Doxorubicin-hydrochloride1.5%1
12
Bevacizumab1.5%1
13
Doxazosin-mesylate1.5%1
14
Escitalopram-oxalate1.5%1
15
Denosumab1.5%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mirdametinib side effects

45.6% of mirdametinib adverse event reports involve female patients and 19.1% involve male patients. The largest age group is adult at 76%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.6%
Male19.1%
Unknown35.3%

Age group

< 23.0%
2–119.1%
12–179.1%
18–6475.8%
65+3.0%

What is mirdametinib used for

Conditions and purposes for which patients were taking mirdametinib when the adverse event was reported.

Central Nervous System NeoplasmChemotherapyDysplasiaGliomaHypertensionNeoplasmNervous System NeoplasmNervous System Neoplasm BenignNeurofibromaNeurofibromatosisOvarian CancerOvarian CancerProduct Used For Unknown Indication

Mirdametinib brand names and reporting trend

Mirdametinib is sold under the brand name Gomekli.

Brand names

Gomekli24

Quarterly reports (20142025)

20142025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mirdametinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.