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Mipomersen Side Effects

The most commonly reported side effects of mipomersen include injection site pain, injection site erythema, and hepatic enzyme increased, based on 287 FDA adverse event reports from 2013 to 2024.

Mipomersen side effects

Percentages show how often each reaction appears relative to total reports for mipomersen.

1
Injection Site Pain28.2%81
2
Injection Site Erythema22.3%64
3
Hepatic Enzyme Increased20.6%59
4
Influenza Like Illness16.0%46
5
Injection Site Bruising13.2%38
6
Fatigue11.8%34
7
Nausea11.1%32
8
Injection Site Discolouration10.1%29
9
Drug Dose Omission9.8%28
10
Injection Site Swelling9.8%28
11
Injection Site Pruritus8.7%25
12
Injection Site Reaction7.7%22
13
Myalgia7.7%22
14
Pain7.3%21
15
Headache7.3%21

These are voluntary reports and do not establish that mipomersen caused these reactions.

Report severity

36.6%Serious105 reports
12.2%Hospitalizations35 reports
0.7%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mipomersen drug interactions

Other drugs that appear in adverse event reports alongside mipomersen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lomitapide-mesylate2.8%8
2
Evolocumab2.4%7
3
Tramadol-hydrochloride0.3%1
4
Amiodarone-hydrochloride0.3%1
5
Insulin0.3%1
6
Fluticasone0.3%1
7
Metoprolol0.3%1
8
Dofetilide0.3%1
9
Oxycodone0.3%1
10
Ranolazine0.3%1
11
Alirocumab0.3%1
12
Rosuvastatin0.3%1

Taken alongside

1
Ezetimibe9.8%28
2
Aspirin8.7%25
3
Rosuvastatin7.3%21
4
Atorvastatin-calcium5.2%15
5
Omeprazole4.5%13
6
Ergocalciferol4.2%12
7
Evolocumab4.2%12
8
Metoprolol3.8%11
9
Acetaminophen3.5%10
10
Nitroglycerin3.5%10
11
Levothyroxine-sodium3.1%9
12
Prednisone3.1%9
13
Isosorbide3.1%9
14
Lisinopril2.8%8
15
Metformin2.4%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mipomersen side effects

59.9% of mipomersen adverse event reports involve female patients and 37.6% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.9%
Male37.6%
Unknown2.4%

Age group

< 20.0%
2–110.8%
12–170.0%
18–6474.0%
65+25.2%

What is mipomersen used for

Conditions and purposes for which patients were taking mipomersen when the adverse event was reported.

Amino Acid Metabolism DisorderBlood Cholesterol AbnormalBlood Cholesterol IncreasedDyslipidaemiaHypercholesterolaemiaHyperlipidaemiaLow Density Lipoprotein IncreasedOff Label UseProduct Used For Unknown IndicationType Iia HyperlipidaemiaType V HyperlipidaemiaType Iia Hyperlipidaemia

Mipomersen brand names and reporting trend

Mipomersen is sold under the brand name Kynamro.

Brand names

Kynamro36

Quarterly reports (20132024)

201320162024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mipomersen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.