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Minocycline Side Effects

The most commonly reported side effects of minocycline include off label use, nausea, and pain, based on 19,936 FDA adverse event reports from 2004 to 2025. 14.2% of reports found the drug to be ineffective.

Minocycline side effects

Percentages show how often each reaction appears relative to total reports for minocycline.

1
Drug Ineffective14.2%2,832
2
Off Label Use10.6%2,108
3
Nausea8.2%1,643
4
Pain8.1%1,606
5
Arthralgia7.4%1,469
6
Fatigue7.3%1,462
7
Drug Intolerance7.3%1,448
8
Rash7.2%1,432
9
Rheumatoid Arthritis7.0%1,392
10
Drug Hypersensitivity6.9%1,375
11
Headache6.4%1,274
12
Joint Swelling6.2%1,231
13
Condition Aggravated5.9%1,181
14
Pneumonia5.7%1,145
15
Dizziness5.5%1,095

These are voluntary reports and do not establish that minocycline caused these reactions.

Report severity

75.9%Serious15,139 reports
33.9%Hospitalizations6,749 reports
14.8%Fatal2,945 reports

Seriousness is determined by the reporter, not by OpenClaim.

Minocycline drug interactions

Other drugs that appear in adverse event reports alongside minocycline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab15.3%3,046
2
Methotrexate13.6%2,703
3
Etanercept13.5%2,690
4
Leflunomide12.7%2,540
5
Rituximab12.7%2,537
6
Hydroxychloroquine-sulfate12.2%2,430
7
Sulfasalazine11.8%2,357
8
Abatacept11.7%2,336
9
Tofacitinib10.5%2,100
10
Tocilizumab10.3%2,053
11
Infliximab9.9%1,979
12
Prednisone9.9%1,975
13
Azathioprine9.7%1,943
14
Certolizumab-pegol9.4%1,878
15
Golimumab9.1%1,816

Taken alongside

1
Acetaminophen11.4%2,275
2
Prednisone8.9%1,768
3
Ergocalciferol8.7%1,737
4
Levothyroxine-sodium6.3%1,263
5
Aspirin6.0%1,191
6
Albuterol5.9%1,173
7
Omeprazole5.5%1,101
8
Lisinopril5.4%1,073
9
Oxycodone5.2%1,030
10
Ibuprofen5.0%1,005
11
Pantoprazole-sodium4.9%982
12
Gabapentin4.8%966
13
Methotrexate4.8%965
14
Furosemide4.8%952
15
Fluticasone4.7%940

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports minocycline side effects

58.2% of minocycline adverse event reports involve female patients and 32.0% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.2%
Male32.0%
Unknown9.8%

Age group

< 20.4%
2–110.8%
12–1710.0%
18–6464.9%
65+23.9%

What is minocycline used for

Conditions and purposes for which patients were taking minocycline when the adverse event was reported.

Abdominal AbscessAbdominal InfectionAbdominal InjuryAbscessAbscess LimbAbscess Of EyelidAcinetobacter InfectionAcneAcne ConglobataAcne CysticAcne FulminansAcne PustularAcne VarioliformisAcne VulgarisActinic Keratosis

Showing 15 of 918 indications

Minocycline brand names and reporting trend

Minocycline is sold under the brand name Dynacin.

Brand names

Dynacin40

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking minocycline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.