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Milrinone Side Effects

The most commonly reported side effects of milrinone include renal failure, pain, and injury, based on 3,077 FDA adverse event reports from 2004 to 2025. 16.0% of reports found the drug to be ineffective.

Milrinone side effects

Percentages show how often each reaction appears relative to total reports for milrinone.

1
Drug Ineffective16.0%492
2
Renal Failure13.4%413
3
Pain13.2%405
4
Injury12.3%380
5
Unevaluable Event11.7%361
6
Anxiety11.5%354
7
Fear10.5%323
8
Emotional Distress8.9%275
9
Renal Injury8.6%266
10
Anhedonia8.1%249
11
Off Label Use7.9%242
12
Stress7.5%231
13
Renal Impairment7.4%228
14
Death6.7%205
15
Multi-organ Failure6.0%184

These are voluntary reports and do not establish that milrinone caused these reactions.

Report severity

94.6%Serious2,910 reports
47.8%Hospitalizations1,472 reports
26.6%Fatal819 reports

Seriousness is determined by the reporter, not by OpenClaim.

Milrinone drug interactions

Other drugs that appear in adverse event reports alongside milrinone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aprotinin14.0%431
2
Epinephrine11.6%357
3
Furosemide5.7%175
4
Amiodarone-hydrochloride5.7%174
5
Heparin5.6%173
6
Sildenafil-citrate4.9%151
7
Nitric-oxide4.9%150
8
Methylprednisolone4.7%146
9
Dobutamine-hydrochloride4.3%132
10
Vasopressin3.6%111
11
Epoprostenol-sodium3.4%104
12
Treprostinil3.3%101
13
Tacrolimus3.2%100
14
Vancomycin3.2%98
15
Digoxin2.8%86

Taken alongside

1
Furosemide28.4%875
2
Epinephrine23.5%722
3
Heparin20.6%634
4
Fentanyl14.9%459
5
Midazolam14.4%443
6
Dobutamine-hydrochloride11.9%366
7
Aspirin11.8%362
8
Potassium-chloride11.7%361
9
Vancomycin11.6%356
10
Insulin10.9%336
11
Dopamine-hydrochloride10.9%335
12
Amiodarone-hydrochloride10.9%334
13
Nitroglycerin10.6%326
14
Metoprolol10.1%311
15
Spironolactone10.0%308

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports milrinone side effects

39.7% of milrinone adverse event reports involve female patients and 47.5% involve male patients. The largest age group is adult at 43%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.7%
Male47.5%
Unknown12.8%

Age group

< 216.7%
2–1110.1%
12–176.8%
18–6443.0%
65+23.4%

What is milrinone used for

Conditions and purposes for which patients were taking milrinone when the adverse event was reported.

Acute Myeloid LeukaemiaAcute Myocardial InfarctionAlveolar Capillary DysplasiaAmyloidosisAngiopathyArrhythmiaArrhythmia SupraventricularAtrial FibrillationAtrial TachycardiaAtrioventricular BlockAcute Kidney InjuryAcute Left Ventricular FailureAffect LabilityAmyloidosisAnaphylactoid Syndrome Of Pregnancy

Showing 15 of 316 indications

Milrinone brand names and reporting trend

Milrinone is sold under the brand name Milrinone Lactate In Dextrose 5% In Plastic Container.

Brand names

Milrinone Lactate In Dextrose 5% In Plastic Container3,183

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking milrinone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.