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Milnacipran Side Effects

The most commonly reported side effects of milnacipran include pain, nausea, and nausea, based on 6,934 FDA adverse event reports from 2004 to 2025. 6.1% of reports found the drug to be ineffective.

Milnacipran side effects

Percentages show how often each reaction appears relative to total reports for milnacipran.

1
Pain6.1%425
2
Drug Ineffective6.1%422
3
Nausea5.8%399
4
Nausea5.6%390
5
Headache4.7%328
6
Off Label Use4.2%292
7
Vomiting3.7%260
8
Fatigue3.7%255
9
Drug Hypersensitivity3.7%255
10
Headache3.4%233
11
Hyperhidrosis2.9%202
12
Depression2.9%201
13
Dizziness2.8%195
14
Insomnia2.8%194
15
Anxiety2.7%190

These are voluntary reports and do not establish that milnacipran caused these reactions.

Report severity

48.3%Serious3,347 reports
19.3%Hospitalizations1,337 reports
3.5%Fatal241 reports

Seriousness is determined by the reporter, not by OpenClaim.

Milnacipran drug interactions

Other drugs that appear in adverse event reports alongside milnacipran. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate7.8%542
2
Pregabalin5.7%394
3
Adalimumab5.5%379
4
Duloxetine-hydrochloride2.8%195
5
Etanercept2.5%173
6
Acetaminophen2.2%156
7
Gabapentin2.2%150
8
Paroxetine2.1%149
9
Pantoprazole-sodium1.9%135
10
Lamotrigine1.7%118
11
Topiramate1.7%118
12
Tramadol-hydrochloride1.7%116
13
Naproxen1.6%112
14
Trazodone-hydrochloride1.5%105
15
Esomeprazole1.5%105

Taken alongside

1
Acetaminophen18.6%1,288
2
Ergocalciferol14.1%976
3
Levothyroxine-sodium14.1%975
4
Gabapentin13.2%916
5
Pregabalin10.9%753
6
Hydrocodone10.2%707
7
Omeprazole9.7%672
8
Oxycodone9.6%667
9
Alprazolam8.0%558
10
Ibuprofen8.0%555
11
Cyclobenzaprine-hydrochloride7.8%540
12
Aspirin7.7%534
13
Tramadol-hydrochloride7.7%532
14
Zolpidem-tartrate7.5%523
15
Albuterol7.2%500

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports milnacipran side effects

82.6% of milnacipran adverse event reports involve female patients and 11.9% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female82.6%
Male11.9%
Unknown5.5%

Age group

< 20.2%
2–11<0.1%
12–170.4%
18–6479.2%
65+20.1%

What is milnacipran used for

Conditions and purposes for which patients were taking milnacipran when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAccidental Drug Intake By ChildAdult Failure To ThriveAffective DisorderAgitationAllodyniaAnalgesic TherapyAnkylosing SpondylitisAntidepressant TherapyAnxietyArthralgiaArthritisAsperger^s DisorderAsthenia

Showing 15 of 185 indications

Milnacipran brand names and reporting trend

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking milnacipran with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.