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Miglustat Side Effects

The most commonly reported side effects of miglustat include death, diarrhoea, and seizure, based on 1,168 FDA adverse event reports from 2004 to 2025.

Miglustat side effects

Percentages show how often each reaction appears relative to total reports for miglustat.

1
Death12.8%150
2
Diarrhoea11.0%129
3
Seizure9.6%112
4
Niemann-pick Disease7.0%82
5
Pneumonia6.9%81
6
Weight Decreased6.5%76
7
Off Label Use6.0%70
8
Disease Progression5.7%66
9
Condition Aggravated5.1%60
10
Dysphagia4.9%57
11
Tremor4.5%53
12
Pyrexia4.5%52
13
Diarrhoea3.9%46
14
Vomiting3.6%42
15
Pneumonia Aspiration3.5%41

These are voluntary reports and do not establish that miglustat caused these reactions.

Report severity

87.4%Serious1,021 reports
36.3%Hospitalizations424 reports
27.5%Fatal321 reports

Seriousness is determined by the reporter, not by OpenClaim.

Miglustat drug interactions

Other drugs that appear in adverse event reports alongside miglustat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cipaglucosidase-alfa-atga5.1%59
2
Imiglucerase2.7%32
3
Levetiracetam1.4%16
4
Levacetylleucine1.4%16
5
Velaglucerase-alfa1.0%12
6
Topiramate0.9%11
7
Aripiprazole0.9%11
8
Alglucosidase-alfa0.8%9
9
Valproate-sodium0.5%6
10
Cannabidiol0.5%6
11
Clobazam0.4%5
12
Lorazepam0.4%5
13
Arimoclomol-citrate0.4%5
14
Valproic-acid0.3%4
15
Taliglucerase-alfa0.3%4

Taken alongside

1
Levetiracetam6.7%78
2
Ergocalciferol3.7%43
3
Lamotrigine3.2%37
4
Acetaminophen2.9%34
5
Ibuprofen2.9%34
6
Clobazam2.9%34
7
Albuterol2.8%33
8
Oxcarbazepine2.7%32
9
Diazepam2.3%27
10
Clonazepam2.2%26
11
Omeprazole2.1%25
12
Calcium2.1%25
13
Gabapentin2.1%25
14
Polyethylene-glycol-33502.1%24
15
Valproic-acid2.0%23

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports miglustat side effects

44.5% of miglustat adverse event reports involve female patients and 41.1% involve male patients. The largest age group is adult at 40%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.5%
Male41.1%
Unknown14.4%

Age group

< 24.7%
2–1133.4%
12–1717.5%
18–6439.8%
65+4.6%

What is miglustat used for

Conditions and purposes for which patients were taking miglustat when the adverse event was reported.

Accidental ExposureBrain Stem GliomaCataplexyDementiaDyspepsiaElectroneurographyEnzyme AbnormalityFabry^s DiseaseGalactosialidosisGaucher's DiseaseGaucher^s DiseaseGaucher^s Disease Type IGaucher^s Disease Type IiGaucher^s Disease Type IiiGlioblastoma Multiforme

Showing 15 of 44 indications

Miglustat brand names and reporting trend

Miglustat is sold under the brand name Zavesca.

Brand names

Zavesca296

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking miglustat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.