OpenClaim

Midodrine Side Effects

The most commonly reported side effects of midodrine include death, hypotension, and fall, based on 15,424 FDA adverse event reports from 2004 to 2025. 4.9% of reports found the drug to be ineffective.

Midodrine side effects

Percentages show how often each reaction appears relative to total reports for midodrine.

1
Death8.6%1,323
2
Hypotension7.2%1,115
3
Fall6.9%1,068
4
Dizziness6.6%1,020
5
Fatigue6.2%957
6
Nausea5.7%873
7
Dyspnoea5.6%862
8
Diarrhoea5.2%807
9
Drug Ineffective4.9%760
10
Headache4.8%740
11
Off Label Use4.6%706
12
Asthenia4.1%629
13
Pneumonia4.0%617
14
Vomiting3.2%491
15
Urinary Tract Infection3.0%458

These are voluntary reports and do not establish that midodrine caused these reactions.

Report severity

72.5%Serious11,181 reports
40.5%Hospitalizations6,252 reports
17.5%Fatal2,701 reports

Seriousness is determined by the reporter, not by OpenClaim.

Midodrine drug interactions

Other drugs that appear in adverse event reports alongside midodrine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Droxidopa8.7%1,344
2
Treprostinil7.5%1,162
3
Pimavanserin6.8%1,046
4
Lenalidomide6.4%984
5
Levodopa6.0%924
6
Carbidopa5.5%851
7
Sodium-oxybate2.9%451
8
Pomalidomide1.9%286
9
Omeprazole1.7%267
10
Pantoprazole-sodium1.6%252
11
Ambrisentan1.6%248
12
Macitentan1.6%245
13
Apixaban1.5%237
14
Dexamethasone1.4%223
15
Fludrocortisone-acetate1.4%215

Taken alongside

1
Acetaminophen22.2%3,429
2
Ergocalciferol20.7%3,190
3
Aspirin20.5%3,162
4
Levothyroxine-sodium16.9%2,612
5
Gabapentin16.5%2,539
6
Pantoprazole-sodium16.2%2,496
7
Atorvastatin-calcium15.6%2,401
8
Furosemide15.1%2,331
9
Ondansetron13.8%2,132
10
Omeprazole13.6%2,102
11
Fludrocortisone-acetate13.5%2,083
12
Albuterol13.1%2,022
13
Carbidopa12.8%1,974
14
Potassium-chloride11.5%1,777
15
Levodopa11.2%1,724

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports midodrine side effects

47.6% of midodrine adverse event reports involve female patients and 45.1% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.6%
Male45.1%
Unknown7.2%

Age group

< 20.3%
2–110.1%
12–172.0%
18–6440.3%
65+57.1%

What is midodrine used for

Conditions and purposes for which patients were taking midodrine when the adverse event was reported.

Abdominal PainAccommodation DisorderAcute Kidney InjuryAdrenal InsufficiencyAmyloidosisAnxietyAscitesAtrial FibrillationAtrial FlutterAutonomic DysreflexiaAutonomic Failure SyndromeAutonomic Nervous System ImbalanceAutonomic NeuropathyAbdominal DiscomfortAcute Coronary Syndrome

Showing 15 of 258 indications

Midodrine brand names and reporting trend

Midodrine is sold under the brand name Orvaten.

Brand names

Orvaten61

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking midodrine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.