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Metyrosine Side Effects

The most commonly reported side effects of metyrosine include off label use, somnolence, and pyrexia, based on 110 FDA adverse event reports from 2004 to 2025. 3.6% of reports found the drug to be ineffective.

Metyrosine side effects

Percentages show how often each reaction appears relative to total reports for metyrosine.

1
Off Label Use13.6%15
2
Somnolence10.0%11
3
Pyrexia8.2%9
4
Diarrhoea5.5%6
5
Pneumonia5.5%6
6
Vomiting4.5%5
7
Fatigue4.5%5
8
Malaise4.5%5
9
Hypotension4.5%5
10
Infection3.6%4
11
Fall3.6%4
12
Drug Ineffective3.6%4
13
Malignant Neoplasm Progression3.6%4
14
Hypoglycaemia3.6%4
15
Insomnia3.6%4

These are voluntary reports and do not establish that metyrosine caused these reactions.

Report severity

85.5%Serious94 reports
40.9%Hospitalizations45 reports
16.4%Fatal18 reports

Seriousness is determined by the reporter, not by OpenClaim.

Metyrosine drug interactions

Other drugs that appear in adverse event reports alongside metyrosine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paclitaxel6.4%7
2
Phenoxybenzamine-hydrochloride3.6%4
3
Pertuzumab3.6%4
4
Trastuzumab3.6%4
5
Cyclophosphamide3.6%4
6
Doxazosin-mesylate3.6%4
7
Doxorubicin-hydrochloride2.7%3
8
Phenytoin2.7%3
9
Methoxsalen2.7%3
10
Sirolimus2.7%3
11
Metyrapone2.7%3
12
Vincristine-sulfate2.7%3
13
Sunitinib-malate1.8%2
14
Metformin1.8%2
15
Ivabradine1.8%2

Taken alongside

1
Doxazosin-mesylate27.3%30
2
Amlodipine12.7%14
3
Magnesium-oxide11.8%13
4
Dexamethasone11.8%13
5
Oxycodone10.0%11
6
Spironolactone9.1%10
7
Bisoprolol-fumarate9.1%10
8
Levothyroxine-sodium8.2%9
9
Vincristine-sulfate8.2%9
10
Pantoprazole-sodium8.2%9
11
Furosemide7.3%8
12
Cyclophosphamide7.3%8
13
Lubiprostone7.3%8
14
Lansoprazole7.3%8
15
Pregabalin7.3%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports metyrosine side effects

44.5% of metyrosine adverse event reports involve female patients and 47.3% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.5%
Male47.3%
Unknown8.2%

Age group

< 24.5%
2–112.2%
12–170.0%
18–6461.8%
65+31.5%

What is metyrosine used for

Conditions and purposes for which patients were taking metyrosine when the adverse event was reported.

AdrenalectomyAdrenocortical Insufficiency AcuteAgitationBack PainBlood Catecholamines IncreasedBlood Pressure HighBlood Pressure ManagementBlood CatecholaminesBlood Catecholamines IncreasedCancer PainChromosomal DeletionChronic Obstructive Pulmonary DiseaseCovid-19CoughDigeorge^s Syndrome

Showing 15 of 45 indications

Metyrosine brand names and reporting trend

Metyrosine is sold under the brand name Metyrosine.

Brand names

Metyrosine42

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking metyrosine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.