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Metyrapone Side Effects

The most commonly reported side effects of metyrapone include off label use, nausea, and vomiting, based on 916 FDA adverse event reports from 2004 to 2025. 6.3% of reports found the drug to be ineffective.

Metyrapone side effects

Percentages show how often each reaction appears relative to total reports for metyrapone.

1
Off Label Use32.9%301
2
Nausea7.8%71
3
Drug Ineffective6.3%58
4
Vomiting4.6%42
5
Fatigue4.4%40
6
Pneumocystis Jirovecii Pneumonia3.8%35
7
Asthenia3.8%35
8
Adrenal Insufficiency3.7%34
9
Dizziness3.5%32
10
Diarrhoea3.2%29
11
Hypokalaemia2.8%26
12
Anaemia2.8%26
13
Cortisol Increased2.8%26
14
Exposure During Pregnancy2.7%25
15
Hyperglycaemia2.7%25

These are voluntary reports and do not establish that metyrapone caused these reactions.

Report severity

70.3%Serious644 reports
34.6%Hospitalizations317 reports
12.3%Fatal113 reports

Seriousness is determined by the reporter, not by OpenClaim.

Metyrapone drug interactions

Other drugs that appear in adverse event reports alongside metyrapone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Mitotane9.4%86
2
Ketoconazole7.9%72
3
Pasireotide6.0%55
4
Etoposide5.8%53
5
Osilodrostat-phosphate4.8%44
6
Cisplatin4.7%43
7
Doxorubicin-hydrochloride3.3%30
8
Hydrocortisone2.8%26
9
Spironolactone2.7%25
10
Octreotide-acetate2.5%23
11
Cabergoline2.1%19
12
Temozolomide2.0%18
13
Nifedipine1.9%17
14
Carboplatin1.9%17
15
Metformin1.7%16

Taken alongside

1
Spironolactone13.0%119
2
Hydrocortisone11.4%104
3
Amlodipine9.5%87
4
Levothyroxine-sodium9.5%87
5
Insulin8.2%75
6
Metformin7.5%69
7
Mitotane7.0%64
8
Ketoconazole6.3%58
9
Ergocalciferol6.1%56
10
Potassium-chloride5.5%50
11
Ondansetron5.3%49
12
Furosemide5.0%46
13
Dexamethasone4.8%44
14
Acetaminophen4.5%41
15
Metoprolol4.4%40

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports metyrapone side effects

59.0% of metyrapone adverse event reports involve female patients and 31.4% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.0%
Male31.4%
Unknown9.6%

Age group

< 23.8%
2–110.9%
12–171.7%
18–6464.0%
65+29.6%

What is metyrapone used for

Conditions and purposes for which patients were taking metyrapone when the adverse event was reported.

Acth Stimulation TestActh-producing Pituitary TumourAdrenal Blockade TherapyAdrenal Gland CancerAdrenal InsufficiencyAdrenocortical CarcinomaAdrenal DisorderAdrenal Gland CancerAdrenal InsufficiencyAdrenocortical CarcinomaBlood Corticotrophin IncreasedBlood Cortisol AbnormalBenign Neoplasm Of Adrenal GlandCarcinoid SyndromeCarcinoid Tumour

Showing 15 of 89 indications

Metyrapone brand names and reporting trend

Metyrapone is sold under the brand name Metopirone.

Brand names

Metopirone579

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking metyrapone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.