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Metoprolol Side Effects

The most commonly reported side effects of metoprolol include fatigue, diarrhoea, and dyspnoea, based on 360,722 FDA adverse event reports from 2004 to 2025. 4.1% of reports found the drug to be ineffective.

Metoprolol side effects

Percentages show how often each reaction appears relative to total reports for metoprolol.

1
Fatigue5.5%19,894
2
Diarrhoea4.6%16,682
3
Dyspnoea4.6%16,446
4
Nausea4.3%15,462
5
Drug Ineffective4.1%14,636
6
Dizziness3.7%13,287
7
Off Label Use3.6%13,148
8
Death3.4%12,290
9
Headache3.0%10,766
10
Asthenia3.0%10,714
11
Fall2.9%10,556
12
Pain2.8%10,208
13
Pneumonia2.3%8,430
14
Hypotension2.2%7,992
15
Vomiting2.2%7,980

These are voluntary reports and do not establish that metoprolol caused these reactions.

Report severity

68.8%Serious248,300 reports
38.4%Hospitalizations138,662 reports
10.8%Fatal38,780 reports

Seriousness is determined by the reporter, not by OpenClaim.

Metoprolol drug interactions

Other drugs that appear in adverse event reports alongside metoprolol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide4.9%17,735
2
Adalimumab3.3%11,799
3
Apixaban2.9%10,411
4
Aspirin2.2%7,850
5
Rivaroxaban2.2%7,845
6
Omeprazole2.1%7,655
7
Amlodipine2.0%7,131
8
Esomeprazole1.9%6,944
9
Dabigatran-etexilate-mesylate1.7%6,195
10
Pantoprazole-sodium1.7%6,154
11
Atorvastatin-calcium1.7%6,019
12
Metformin1.6%5,662
13
Valsartan1.5%5,555
14
Rosiglitazone-maleate1.5%5,316
15
Lisinopril1.4%4,979

Taken alongside

1
Aspirin26.5%95,670
2
Atorvastatin-calcium18.3%66,017
3
Furosemide16.5%59,558
4
Amlodipine14.9%53,654
5
Acetaminophen13.9%50,114
6
Levothyroxine-sodium13.7%49,403
7
Lisinopril13.2%47,458
8
Ergocalciferol13.0%47,020
9
Omeprazole11.8%42,487
10
Metformin11.0%39,681
11
Pantoprazole-sodium10.4%37,431
12
Simvastatin10.0%36,162
13
Gabapentin9.0%32,421
14
Albuterol8.5%30,561
15
Insulin8.4%30,154

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports metoprolol side effects

50.6% of metoprolol adverse event reports involve female patients and 43.3% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.6%
Male43.3%
Unknown6.1%

Age group

< 20.4%
2–110.1%
12–170.3%
18–6439.4%
65+59.8%

What is metoprolol used for

Conditions and purposes for which patients were taking metoprolol when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAbdominal Pain UpperAccelerated Idioventricular RhythmAccessory Cardiac PathwayAccidental ExposureAccidental Exposure To ProductAccidental OverdoseAcid Base BalanceAcneAcute Coronary SyndromeAcute Left Ventricular FailureAcute Myocardial InfarctionAcute Respiratory Distress SyndromeAcute Respiratory Failure

Showing 15 of 1,336 indications

Metoprolol brand names and reporting trend

Metoprolol is sold under brand names including Metoprolol Succinate, Lopressor.

Brand names

Metoprolol Succinate69,036
Lopressor5

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking metoprolol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.