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Metoclopramide Side Effects

The most commonly reported side effects of metoclopramide include tardive dyskinesia, extrapyramidal disorder, and nervous system disorder, based on 81,376 FDA adverse event reports from 2004 to 2025.

Metoclopramide side effects

Percentages show how often each reaction appears relative to total reports for metoclopramide.

1
Tardive Dyskinesia18.0%14,610
2
Extrapyramidal Disorder14.7%11,950
3
Nervous System Disorder8.7%7,061
4
Dystonia8.1%6,551
5
Nausea6.4%5,225
6
Pain5.2%4,211
7
Economic Problem4.9%3,957
8
Vomiting4.7%3,846
9
Diarrhoea4.2%3,426
10
Incorrect Drug Administration Duration4.0%3,233
11
Anxiety3.8%3,052
12
Movement Disorder3.7%3,036
13
Off Label Use3.7%3,008
14
Fatigue3.7%3,000
15
Activities Of Daily Living Impaired3.6%2,945

These are voluntary reports and do not establish that metoclopramide caused these reactions.

Report severity

89.2%Serious72,591 reports
44.9%Hospitalizations36,531 reports
13.2%Fatal10,709 reports

Seriousness is determined by the reporter, not by OpenClaim.

Metoclopramide drug interactions

Other drugs that appear in adverse event reports alongside metoclopramide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone3.4%2,795
2
Cyclophosphamide3.2%2,644
3
Carboplatin3.2%2,588
4
Omeprazole3.0%2,404
5
Acetaminophen3.0%2,403
6
Paclitaxel3.0%2,402
7
Ondansetron2.8%2,286
8
Pantoprazole-sodium2.4%1,929
9
Doxorubicin-hydrochloride2.3%1,866
10
Trastuzumab2.2%1,784
11
Lenalidomide2.1%1,730
12
Rituximab2.1%1,696
13
Oxaliplatin2.0%1,649
14
Bevacizumab2.0%1,628
15
Esomeprazole2.0%1,626

Taken alongside

1
Acetaminophen22.2%18,038
2
Ondansetron16.8%13,689
3
Omeprazole13.1%10,684
4
Pantoprazole-sodium12.0%9,753
5
Dexamethasone11.3%9,164
6
Furosemide10.5%8,525
7
Aspirin9.8%7,985
8
Albuterol8.2%6,640
9
Oxycodone8.1%6,552
10
Levothyroxine-sodium7.6%6,200
11
Amlodipine7.6%6,182
12
Lorazepam7.5%6,071
13
Gabapentin6.7%5,475
14
Insulin6.6%5,342
15
Atorvastatin-calcium6.5%5,272

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports metoclopramide side effects

57.3% of metoclopramide adverse event reports involve female patients and 33.4% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.3%
Male33.4%
Unknown9.3%

Age group

< 21.4%
2–111.7%
12–171.7%
18–6457.6%
65+37.6%

What is metoclopramide used for

Conditions and purposes for which patients were taking metoclopramide when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal SymptomAbortion InducedAbscess IntestinalAccidental Exposure To ProductAcid DyspepsiaAcid RefluxAcid Reflux (esophageal)AcidosisAcromegalyAcute Kidney Injury

Showing 15 of 940 indications

Metoclopramide brand names and reporting trend

Metoclopramide is sold under the brand name Maxolon.

Brand names

Maxolon127

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking metoclopramide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.