OpenClaim

Methysergide Side Effects

The most commonly reported side effects of methysergide include migraine, abdominal pain lower, and headache, based on 64 FDA adverse event reports from 2004 to 2025. 15.6% of reports found the drug to be ineffective.

Methysergide side effects

Percentages show how often each reaction appears relative to total reports for methysergide.

1
Drug Ineffective15.6%10
2
Migraine12.5%8
3
Abdominal Pain Lower9.4%6
4
Headache9.4%6
5
Dizziness7.8%5
6
Polyp7.8%5
7
Abdominal Discomfort7.8%5
8
Haematochezia7.8%5
9
Weight Increased7.8%5
10
Fatigue6.3%4
11
Nausea6.3%4
12
Somnolence6.3%4
13
Drug Hypersensitivity6.3%4
14
Vomiting4.7%3
15
Aggression4.7%3

These are voluntary reports and do not establish that methysergide caused these reactions.

Report severity

87.5%Serious56 reports
28.1%Hospitalizations18 reports
1.6%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methysergide drug interactions

Other drugs that appear in adverse event reports alongside methysergide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Verapamil-hydrochloride18.8%12
2
Topiramate17.2%11
3
Amitriptyline-hydrochloride17.2%11
4
Gabapentin15.6%10
5
Dihydroergotamine-mesylate14.1%9
6
Venlafaxine12.5%8
7
Propranolol-hydrochloride12.5%8
8
Pregabalin9.4%6
9
Erenumab-aooe9.4%6
10
Valproic-acid7.8%5
11
Ketorolac-tromethamine7.8%5
12
Meperidine-hydrochloride7.8%5
13
Metoprolol6.3%4
14
Codeine4.7%3
15
Valproate-sodium4.7%3

Taken alongside

1
Sumatriptan10.9%7
2
Propranolol-hydrochloride9.4%6
3
Tamsulosin-hydrochloride6.3%4
4
Valproate-sodium6.3%4
5
Amoxicillin4.7%3
6
Amantadine4.7%3
7
Levothyroxine-sodium4.7%3
8
Fluticasone4.7%3
9
Amitriptyline-hydrochloride4.7%3
10
Dihydroergotamine-mesylate4.7%3
11
Olanzapine4.7%3
12
Lorazepam3.1%2
13
Omeprazole3.1%2
14
Estradiol3.1%2
15
Cyclobenzaprine-hydrochloride3.1%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methysergide side effects

53.1% of methysergide adverse event reports involve female patients and 35.9% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.1%
Male35.9%
Unknown10.9%

Age group

< 22.0%
2–112.0%
12–176.0%
18–6462.0%
65+28.0%

What is methysergide used for

Conditions and purposes for which patients were taking methysergide when the adverse event was reported.

Cluster HeadacheCluster HeadachesDrug Use For Unknown IndicationHeadacheMigraineMigraine ProphylaxisNew Daily Persistent HeadacheProduct Used For Unknown IndicationProduct Used For Unknown IndicationProphylaxis

Methysergide brand names and reporting trend

Methysergide is sold under the brand name Sansert.

Brand names

Sansert49

Quarterly reports (20042025)

20042005201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methysergide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.