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Methylergonovine Side Effects

The most commonly reported side effects of methylergonovine include wrong drug administered, drug exposure during pregnancy, and vomiting, based on 731 FDA adverse event reports from 2004 to 2025. 6.6% of reports found the drug to be ineffective.

Methylergonovine side effects

Percentages show how often each reaction appears relative to total reports for methylergonovine.

1
Wrong Drug Administered8.6%63
2
Drug Exposure During Pregnancy7.0%51
3
Drug Ineffective6.6%48
4
Vomiting5.1%37
5
Abdominal Pain3.8%28
6
Dyspnoea3.8%28
7
Maternal Exposure During Pregnancy3.4%25
8
Headache3.1%23
9
Nausea3.1%23
10
Off Label Use3.1%23
11
Cyanosis3.0%22
12
Nausea3.0%22
13
Accidental Exposure2.9%21
14
Medication Error2.6%19
15
Haemorrhage2.6%19

These are voluntary reports and do not establish that methylergonovine caused these reactions.

Report severity

90.3%Serious660 reports
41.6%Hospitalizations304 reports
6.0%Fatal44 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methylergonovine drug interactions

Other drugs that appear in adverse event reports alongside methylergonovine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxytocin11.2%82
2
Misoprostol5.3%39
3
Carboprost-tromethamine5.3%39
4
Ethinyl-estradiol3.4%25
5
Drospirenone3.1%23
6
Acetaminophen3.0%22
7
Bupivacaine2.6%19
8
Tranexamic-acid2.5%18
9
Zolpidem-tartrate2.2%16
10
Prochlorperazine2.2%16
11
Vitamin-k2.1%15
12
Quetiapine-fumarate2.1%15
13
Verapamil-hydrochloride1.8%13
14
Paroxetine1.5%11
15
Lidocaine1.5%11

Taken alongside

1
Acetaminophen6.4%47
2
Oxytocin5.9%43
3
Ibuprofen5.9%43
4
Misoprostol3.8%28
5
Ondansetron3.6%26
6
Prednisone3.3%24
7
Gabapentin3.1%23
8
Fentanyl3.0%22
9
Hydrocodone2.6%19
10
Albuterol2.6%19
11
Oxycodone2.5%18
12
Doxycycline2.3%17
13
Diphenhydramine2.2%16
14
Fluticasone2.1%15
15
Promethazine-hydrochloride2.1%15

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methylergonovine side effects

78.1% of methylergonovine adverse event reports involve female patients and 12.6% involve male patients. The largest age group is adult at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female78.1%
Male12.6%
Unknown9.3%

Age group

< 213.0%
2–111.0%
12–172.9%
18–6479.8%
65+3.3%

What is methylergonovine used for

Conditions and purposes for which patients were taking methylergonovine when the adverse event was reported.

Abdominal PainAbnormal LabourAbortionAbortion IncompleteAbortion Incomplete ComplicatedAbortion InducedAbortion MissedAbortion SpontaneousAbortion ThreatenedAccidental ExposureAfterbirth PainAnaesthesiaAneurysmArteriovenous MalformationAbortion

Showing 15 of 98 indications

Methylergonovine brand names and reporting trend

Methylergonovine is sold under the brand name Methylergonovine Maleate.

Brand names

Methylergonovine Maleate48

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methylergonovine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.