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Methyldopate Side Effects

The most commonly reported side effects of methyldopate include drug exposure during pregnancy, maternal exposure during pregnancy, and foetal exposure during pregnancy, based on 1,244 FDA adverse event reports from 2004 to 2025.

Methyldopate side effects

Percentages show how often each reaction appears relative to total reports for methyldopate.

1
Drug Exposure During Pregnancy10.2%127
2
Maternal Exposure During Pregnancy6.0%75
3
Foetal Exposure During Pregnancy5.0%62
4
Hypertension4.0%50
5
Hypertension3.8%47
6
Exposure During Pregnancy3.5%43
7
Premature Baby3.4%42
8
Caesarean Section3.2%40
9
Premature Baby3.0%37
10
Nausea2.9%36
11
Dizziness2.7%33
12
Blood Pressure Increased2.2%27
13
Headache2.1%26
14
Foetal Growth Restriction2.1%26
15
Premature Delivery2.1%26

These are voluntary reports and do not establish that methyldopate caused these reactions.

Report severity

89.9%Serious1,118 reports
48.5%Hospitalizations603 reports
10.0%Fatal124 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methyldopate drug interactions

Other drugs that appear in adverse event reports alongside methyldopate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methyldopa28.9%359
2
Valsartan6.0%75
3
Amlodipine3.7%46
4
Insulin3.5%43
5
Metformin3.1%39
6
Hydrochlorothiazide3.1%38
7
Tacrolimus2.7%33
8
Labetalol-hydrochloride2.4%30
9
Nifedipine2.3%29
10
Hydralazine-hydrochloride2.3%29
11
Lisinopril2.3%29
12
Furosemide2.3%29
13
Paroxetine2.0%25
14
Prednisone1.6%20
15
Amoxicillin1.4%17

Taken alongside

1
Methyldopa70.8%881
2
Nifedipine12.2%152
3
Furosemide11.9%148
4
Aspirin11.8%147
5
Amlodipine10.2%127
6
Hydrochlorothiazide7.6%94
7
Insulin7.6%94
8
Acetaminophen5.9%73
9
Atenolol5.8%72
10
Metformin5.7%71
11
Labetalol-hydrochloride5.5%69
12
Levothyroxine-sodium5.0%62
13
Prednisone4.7%59
14
Folic-acid4.6%57
15
Atorvastatin-calcium4.3%53

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methyldopate side effects

63.8% of methyldopate adverse event reports involve female patients and 29.8% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.8%
Male29.8%
Unknown6.4%

Age group

< 28.9%
2–110.2%
12–170.1%
18–6451.1%
65+39.6%

What is methyldopate used for

Conditions and purposes for which patients were taking methyldopate when the adverse event was reported.

Albumin Globulin Ratio AbnormalBlood PressureBlood Pressure AbnormalBlood Pressure IncreasedBlood Pressure ManagementBlood Pressure MeasurementBone DisorderBlood Pressure DecreasedBlood Pressure IncreasedBlood Pressure ManagementCardiomyopathyCerebral Small Vessel Ischaemic DiseaseDepressionDrug Exposure During PregnancyDrug Use For Unknown Indication

Showing 15 of 47 indications

Methyldopate brand names and reporting trend

Methyldopate is sold under the brand name Methyldopate Hydrochloride.

Brand names

Methyldopate Hydrochloride8

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methyldopate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.