OpenClaim

Methyl Side Effects

The most commonly reported side effects of methyl include pruritus, application site pain, and diarrhoea, based on 1,284 FDA adverse event reports from 2004 to 2025. 13.2% of reports found the drug to be ineffective.

Methyl side effects

Percentages show how often each reaction appears relative to total reports for methyl.

1
Drug Ineffective13.2%170
2
Pruritus6.2%80
3
Application Site Pain5.9%76
4
Diarrhoea5.8%75
5
Off Label Use5.6%72
6
Pain5.4%69
7
Nausea5.1%65
8
Arthralgia5.1%65
9
Fatigue5.1%65
10
Pneumonia4.7%60
11
Rash4.5%58
12
Dyspnoea4.4%56
13
Headache4.4%56
14
Intentional Product Misuse4.2%54
15
Hypertension4.1%53

These are voluntary reports and do not establish that methyl caused these reactions.

Report severity

59.7%Serious767 reports
22.0%Hospitalizations282 reports
4.9%Fatal63 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methyl drug interactions

Other drugs that appear in adverse event reports alongside methyl. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Menthol27.8%357
2
Treprostinil4.3%55
3
Adalimumab3.6%46
4
Abatacept3.5%45
5
Methotrexate3.3%42
6
Etanercept3.2%41
7
Rituximab3.1%40
8
Sulfasalazine3.1%40
9
Infliximab3.0%39
10
Azathioprine3.0%39
11
Hydroxychloroquine-sulfate3.0%39
12
Leflunomide3.0%39
13
Tocilizumab3.0%39
14
Lenalidomide2.3%29
15
Sodium-oxybate2.2%28

Taken alongside

1
Acetaminophen24.7%317
2
Menthol24.0%308
3
Ergocalciferol13.2%169
4
Aspirin12.2%157
5
Albuterol10.3%132
6
Omeprazole9.9%127
7
Atorvastatin-calcium9.7%125
8
Furosemide9.6%123
9
Ibuprofen8.8%113
10
Levothyroxine-sodium8.5%109
11
Gabapentin8.3%107
12
Metoprolol7.7%99
13
Amlodipine7.6%97
14
Lidocaine7.5%96
15
Potassium-chloride6.9%88

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methyl side effects

60.3% of methyl adverse event reports involve female patients and 31.2% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.3%
Male31.2%
Unknown8.6%

Age group

< 20.4%
2–111.1%
12–171.7%
18–6445.8%
65+51.0%

What is methyl used for

Conditions and purposes for which patients were taking methyl when the adverse event was reported.

AcanthomaAccidental Drug Intake By ChildAccidental ExposureAcneActinic KeratosisAcute Myocardial InfarctionAlcohol PoisoningAlcohol UseAlcoholismAnalgesiaAnalgesic TherapyArthralgiaArthritisAnalgesic TherapyArthralgia

Showing 15 of 128 indications

Methyl brand names and reporting trend

Methyl is sold under brand names including Salonpas, Metvixia.

Brand names

Salonpas533
Metvixia43

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methyl with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.