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Methyclothiazide Side Effects

The most commonly reported side effects of methyclothiazide include autoimmune hepatitis, nausea, and diarrhoea, based on 106 FDA adverse event reports from 2004 to 2025. 3.8% of reports found the drug to be ineffective.

Methyclothiazide side effects

Percentages show how often each reaction appears relative to total reports for methyclothiazide.

1
Autoimmune Hepatitis7.5%8
2
Nausea6.6%7
3
Diarrhoea6.6%7
4
Rash4.7%5
5
Arthralgia4.7%5
6
Fatigue3.8%4
7
Dyspnoea3.8%4
8
Hypersensitivity3.8%4
9
Nausea3.8%4
10
Oedema Peripheral3.8%4
11
Pain3.8%4
12
Headache3.8%4
13
Somnolence3.8%4
14
Drug Ineffective3.8%4
15
Bradycardia2.8%3

These are voluntary reports and do not establish that methyclothiazide caused these reactions.

Report severity

69.8%Serious74 reports
29.2%Hospitalizations31 reports
8.5%Fatal9 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methyclothiazide drug interactions

Other drugs that appear in adverse event reports alongside methyclothiazide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Anastrozole7.5%8
2
Tiotropium-bromide4.7%5
3
Adalimumab3.8%4
4
Rosuvastatin2.8%3
5
Pregabalin2.8%3
6
Topiramate2.8%3
7
Digoxin2.8%3
8
Dalfampridine2.8%3
9
Lenalidomide2.8%3
10
Teriparatide1.9%2
11
Tramadol-hydrochloride1.9%2
12
Infliximab1.9%2
13
Rofecoxib1.9%2
14
Rosiglitazone-maleate1.9%2
15
Ranitidine1.9%2

Taken alongside

1
Levothyroxine-sodium25.5%27
2
Pargyline-hydrochloride24.5%26
3
Acetaminophen21.7%23
4
Aspirin19.8%21
5
Deserpidine18.9%20
6
Furosemide17.9%19
7
Albuterol15.1%16
8
Potassium-chloride14.2%15
9
Ergocalciferol13.2%14
10
Ibuprofen12.3%13
11
Clopidogrel-bisulfate11.3%12
12
Lisinopril11.3%12
13
Warfarin9.4%10
14
Amlodipine8.5%9
15
Hydrochlorothiazide8.5%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methyclothiazide side effects

73.6% of methyclothiazide adverse event reports involve female patients and 22.6% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female73.6%
Male22.6%
Unknown3.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6439.4%
65+60.6%

What is methyclothiazide used for

Conditions and purposes for which patients were taking methyclothiazide when the adverse event was reported.

Drug Use For Unknown IndicationFluid RetentionHypertensionLung AdenocarcinomaOedemaOsteoporosis ProphylaxisProduct Used For Unknown IndicationPainProduct Used For Unknown Indication

Methyclothiazide brand names and reporting trend

Methyclothiazide is sold under the brand name Aquatensen.

Brand names

Aquatensen39

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methyclothiazide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.