OpenClaim

Methoxyflurane Side Effects

The most commonly reported side effects of methoxyflurane include renal impairment, bone marrow failure, and vomiting, based on 62 FDA adverse event reports from 2004 to 2025. 9.7% of reports found the drug to be ineffective.

#1 Reported: Renal ImpairmentAll side effects ↓Top Co-Medication: DexamethasoneDrug interactions ↓65% of Reports Are AdultDemographics ↓

Methoxyflurane side effects

Percentages show how often each reaction appears relative to total reports for methoxyflurane.

1
Renal Impairment16.1%10
2
Bone Marrow Failure12.9%8
3
Vomiting11.3%7
4
Sepsis11.3%7
5
Drug Ineffective9.7%6
6
Myocardial Infarction9.7%6
7
Pain In Extremity9.7%6
8
Pneumonia9.7%6
9
Pyrexia8.1%5
10
Febrile Neutropenia8.1%5
11
Fluorosis8.1%5
12
Intentional Product Misuse8.1%5
13
Abnormal Faeces8.1%5
14
Blood Pressure Increased8.1%5
15
Brain Fog8.1%5

These are voluntary reports and do not establish that methoxyflurane caused these reactions.

Report severity

98.4%Serious61 reports
53.2%Hospitalizations33 reports
9.7%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methoxyflurane drug interactions

Other drugs that appear in adverse event reports alongside methoxyflurane. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone32.3%20
2
Rituximab19.4%12
3
Gemcitabine16.1%10
4
Cisplatin14.5%9
5
Carboplatin14.5%9
6
Azacitidine12.9%8
7
Tocilizumab12.9%8
8
Mesna11.3%7
9
Etoposide11.3%7
10
Ifosfamide11.3%7
11
Blinatumomab8.1%5
12
Cyclophosphamide8.1%5
13
Bortezomib8.1%5
14
Zoledronic-acid8.1%5
15
Amlodipine8.1%5

Taken alongside

1
Acetaminophen48.4%30
2
Metoclopramide-hydrochloride40.3%25
3
Lidocaine37.1%23
4
Ondansetron30.6%19
5
Oxycodone30.6%19
6
Sodium-chloride30.6%19
7
Temazepam27.4%17
8
Allopurinol27.4%17
9
Pantoprazole-sodium25.8%16
10
Filgrastim25.8%16
11
Acyclovir25.8%16
12
Fentanyl24.2%15
13
Loratadine21.0%13
14
Potassium-chloride19.4%12
15
Trimethoprim17.7%11

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methoxyflurane side effects

46.8% of methoxyflurane adverse event reports involve female patients and 43.5% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.8%
Male43.5%
Unknown9.7%

Age group

< 21.8%
2–111.8%
12–173.6%
18–6465.5%
65+27.3%

What is methoxyflurane used for

Conditions and purposes for which patients were taking methoxyflurane when the adverse event was reported.

AnaesthesiaAnaesthesia ProcedureAnaesthetic PremedicationArthralgiaBiopsy Bone MarrowLocal AnaesthesiaMigraineMuscle SpasmsNon-hodgkin^s LymphomaPainPain ProphylaxisProduct Used For Unknown IndicationPainPlasma Cell MyelomaProcedural Pain

Showing 15 of 18 indications

Methoxyflurane brand names and reporting trend

Methoxyflurane is sold under the brand name Penthrane.

Brand names

Penthrane71

Quarterly reports (2004–2025)

20042025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methoxyflurane with another medication?

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