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Methocarbamol Side Effects

The most commonly reported side effects of methocarbamol include pain, fatigue, and nausea, based on 22,338 FDA adverse event reports from 2004 to 2025. 6.2% of reports found the drug to be ineffective.

Methocarbamol side effects

Percentages show how often each reaction appears relative to total reports for methocarbamol.

1
Pain6.6%1,482
2
Fatigue6.5%1,463
3
Nausea6.4%1,420
4
Drug Ineffective6.2%1,378
5
Headache4.9%1,097
6
Diarrhoea4.5%1,014
7
Fall4.4%986
8
Arthralgia4.0%898
9
Off Label Use4.0%887
10
Dyspnoea3.9%867
11
Dizziness3.6%803
12
Back Pain3.5%778
13
Chronic Kidney Disease3.5%774
14
Anxiety3.3%726
15
Vomiting3.1%682

These are voluntary reports and do not establish that methocarbamol caused these reactions.

Report severity

62.8%Serious14,020 reports
30.5%Hospitalizations6,818 reports
7.6%Fatal1,705 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methocarbamol drug interactions

Other drugs that appear in adverse event reports alongside methocarbamol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate6.6%1,467
2
Lenalidomide5.1%1,131
3
Adalimumab4.2%944
4
Omeprazole3.8%843
5
Acetaminophen3.7%825
6
Gabapentin3.5%779
7
Esomeprazole3.4%752
8
Dupilumab3.3%735
9
Pregabalin3.2%719
10
Pantoprazole-sodium3.1%693
11
Oxycodone2.6%586
12
Tramadol-hydrochloride2.1%472
13
Etanercept2.1%467
14
Ibuprofen2.0%440
15
Lansoprazole1.9%415

Taken alongside

1
Acetaminophen32.9%7,360
2
Gabapentin27.3%6,099
3
Ergocalciferol21.1%4,716
4
Oxycodone18.2%4,067
5
Albuterol18.1%4,037
6
Aspirin17.5%3,918
7
Omeprazole16.3%3,640
8
Ibuprofen15.8%3,527
9
Levothyroxine-sodium15.7%3,504
10
Hydrocodone15.5%3,452
11
Fluticasone14.2%3,165
12
Ondansetron13.9%3,094
13
Tramadol-hydrochloride13.8%3,075
14
Atorvastatin-calcium13.0%2,896
15
Prednisone12.4%2,778

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methocarbamol side effects

66.1% of methocarbamol adverse event reports involve female patients and 27.8% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female66.1%
Male27.8%
Unknown6.1%

Age group

< 2<0.1%
2–110.7%
12–170.7%
18–6469.2%
65+29.3%

What is methocarbamol used for

Conditions and purposes for which patients were taking methocarbamol when the adverse event was reported.

Abdominal PainAccidentAdverse EventAffective DisorderAlcohol Withdrawal SyndromeAnalgesic TherapyAngina PectorisAnkylosing SpondylitisAntiinflammatory TherapyAntiplatelet TherapyAnxietyArthralgiaArthritisArthropathyAsthma

Showing 15 of 361 indications

Methocarbamol brand names and reporting trend

Methocarbamol is sold under the brand name Delaxin.

Brand names

Delaxin17,109

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methocarbamol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.