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Methixene Side Effects

The most commonly reported side effects of methixene include pneumonia, dyspnoea, and nausea, based on 83 FDA adverse event reports from 2006 to 2025. 3.6% of reports found the drug to be ineffective.

Methixene side effects

Percentages show how often each reaction appears relative to total reports for methixene.

1
Pneumonia8.4%7
2
Dyspnoea6.0%5
3
Nausea6.0%5
4
Asthenia4.8%4
5
Chronic Obstructive Pulmonary Disease3.6%3
6
Decreased Appetite3.6%3
7
Urinary Tract Infection3.6%3
8
Upper Respiratory Tract Infection3.6%3
9
Dysphagia3.6%3
10
Pleural Effusion3.6%3
11
Drug Ineffective3.6%3
12
Headache3.6%3
13
Haematochezia3.6%3
14
Melaena3.6%3
15
Pyrexia3.6%3

These are voluntary reports and do not establish that methixene caused these reactions.

Report severity

83.1%Serious69 reports
61.4%Hospitalizations51 reports
13.3%Fatal11 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methixene drug interactions

Other drugs that appear in adverse event reports alongside methixene. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Atezolizumab8.4%7
2
Cisplatin7.2%6
3
Adalimumab6.0%5
4
Vilanterol-trifenatate4.8%4
5
Ribociclib4.8%4
6
Empagliflozin4.8%4
7
Vedolizumab4.8%4
8
Acetaminophen3.6%3
9
Gemcitabine3.6%3
10
Venetoclax3.6%3
11
Valsartan2.4%2
12
Lisinopril2.4%2
13
Porfimer-sodium2.4%2
14
Ticagrelor2.4%2
15
Pembrolizumab2.4%2

Taken alongside

1
Acetaminophen26.5%22
2
Furosemide24.1%20
3
Aspirin20.5%17
4
Amlodipine18.1%15
5
Megestrol-acetate16.9%14
6
Tramadol-hydrochloride15.7%13
7
Carvedilol14.5%12
8
Atorvastatin-calcium14.5%12
9
Ceftriaxone-sodium12.0%10
10
Metoclopramide-hydrochloride12.0%10
11
Ergocalciferol10.8%9
12
Oxycodone10.8%9
13
Acetylcysteine10.8%9
14
Dexamethasone10.8%9
15
Esomeprazole9.6%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methixene side effects

43.4% of methixene adverse event reports involve female patients and 51.8% involve male patients. The largest age group is elderly at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.4%
Male51.8%
Unknown4.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6435.6%
65+64.4%

What is methixene used for

Conditions and purposes for which patients were taking methixene when the adverse event was reported.

Appetite DisorderAdverse EventBlood Pressure AbnormalCardiac FailureCardiac Valve DiseaseDecreased AppetiteDiabetes MellitusDecreased AppetiteHypertensionIncreased AppetiteInfection ProphylaxisMyocardial InfarctionNeoplasm MalignantProduct Used For Unknown IndicationProphylaxis

Showing 15 of 22 indications

Methixene brand names and reporting trend

Methixene is sold under the brand name Trest.

Brand names

Trest1

Quarterly reports (20062025)

2006201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methixene with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.