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Methicillin Side Effects

The most commonly reported side effects of methicillin include chronic kidney disease, acute kidney injury, and drug resistance, based on 34 FDA adverse event reports from 2004 to 2025. 11.8% of reports found the drug to be ineffective.

Methicillin side effects

Percentages show how often each reaction appears relative to total reports for methicillin.

1
Chronic Kidney Disease14.7%5
2
Acute Kidney Injury11.8%4
3
Drug Resistance11.8%4
4
Drug Ineffective11.8%4
5
End Stage Renal Disease11.8%4
6
Renal Failure8.8%3
7
Off Label Use8.8%3
8
Sepsis8.8%3
9
Haemorrhage5.9%2
10
Pyrexia5.9%2
11
Gastric Cancer5.9%2
12
Staphylococcal Infection5.9%2
13
Nephrogenic Anaemia5.9%2
14
Gastrooesophageal Reflux Disease5.9%2
15
Pathogen Resistance5.9%2

These are voluntary reports and do not establish that methicillin caused these reactions.

Report severity

100.0%Serious34 reports
47.1%Hospitalizations16 reports
17.6%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methicillin drug interactions

Other drugs that appear in adverse event reports alongside methicillin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole23.5%8
2
Pantoprazole-sodium20.6%7
3
Esomeprazole17.6%6
4
Lansoprazole17.6%6
5
Vancomycin11.8%4
6
Meropenem11.8%4
7
Etoposide5.9%2
8
Prednisolone5.9%2
9
Levofloxacin5.9%2
10
Erythromycin5.9%2
11
Ciprofloxacin5.9%2
12
Methylprednisolone5.9%2
13
Gentamicin-sulfate2.9%1
14
Aprotinin2.9%1
15
Carboplatin2.9%1

Taken alongside

1
Lisinopril23.5%8
2
Vancomycin23.5%8
3
Gentamicin-sulfate23.5%8
4
Ciprofloxacin23.5%8
5
Tobramycin23.5%8
6
Cefazolin-sodium23.5%8
7
Amikacin-sulfate20.6%7
8
Hydralazine-hydrochloride20.6%7
9
Ampicillin20.6%7
10
Amoxicillin17.6%6
11
Aspirin17.6%6
12
Ceftriaxone-sodium17.6%6
13
Furosemide17.6%6
14
Simvastatin17.6%6
15
Trimethoprim17.6%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methicillin side effects

44.1% of methicillin adverse event reports involve female patients and 38.2% involve male patients. The largest age group is adult at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.1%
Male38.2%
Unknown17.6%

Age group

< 23.4%
2–1110.3%
12–170.0%
18–6448.3%
65+37.9%

What is methicillin used for

Conditions and purposes for which patients were taking methicillin when the adverse event was reported.

Arthritis InfectiveBacteraemiaDevice Related InfectionEndocarditisEnterocolitis InfectiousFoetal Exposure During PregnancyInfectionInfectionProduct Used For Unknown IndicationPromotion Of Peripheral CirculationPyrexiaProduct Used For Unknown IndicationStaphylococcal InfectionStaphylococcal SepsisWound Infection

Methicillin brand names and reporting trend

Methicillin is sold under the brand name Staphcillin.

Brand names

Staphcillin37

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methicillin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.