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Methamphetamine Side Effects

The most commonly reported side effects of methamphetamine include drug abuse, toxicity to various agents, and cardio-respiratory arrest, based on 1,236 FDA adverse event reports from 2004 to 2025. 1.4% of reports found the drug to be ineffective.

#1 Reported: Drug AbuseAll side effects ↓Top Co-Medication: FentanylDrug interactions ↓93% of Reports Are AdultDemographics ↓

Methamphetamine side effects

Percentages show how often each reaction appears relative to total reports for methamphetamine.

1
Drug Abuse37.0%457
2
Toxicity To Various Agents19.7%244
3
Cardio-respiratory Arrest6.6%82
4
Completed Suicide6.1%75
5
Pulmonary Arterial Hypertension5.8%72
6
Cardiomyopathy5.0%62
7
Death2.8%34
8
Off Label Use2.8%34
9
Drug Abuser2.4%30
10
Overdose2.2%27
11
Drug Dependence1.5%19
12
Toxicity To Various Agents1.5%18
13
Cardiac Arrest1.5%18
14
Depression1.5%18
15
Product Availability Issue1.5%18

These are voluntary reports and do not establish that methamphetamine caused these reactions.

Report severity

88.8%Serious1,098 reports
17.6%Hospitalizations217 reports
55.6%Fatal687 reports

Seriousness is determined by the reporter, not by OpenClaim.

Methamphetamine drug interactions

Other drugs that appear in adverse event reports alongside methamphetamine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Fentanyl13.7%169
2
Amphetamine12.6%156
3
Sodium-oxybate12.1%150
4
Alprazolam9.3%115
5
Oxycodone8.2%101
6
Gabapentin6.3%78
7
Acetaminophen5.1%63
8
Diazepam4.9%61
9
Cocaine-hydrochloride4.5%56
10
Buprenorphine4.5%56
11
Diphenhydramine4.3%53
12
Bupropion4.0%50
13
Alcohol4.0%49
14
Hydrocodone3.6%44
15
Methadone-hydrochloride3.5%43

Taken alongside

1
Dextroamphetamine8.0%99
2
Amphetamine7.9%98
3
Acetaminophen6.6%81
4
Ergocalciferol4.7%58
5
Ibuprofen4.2%52
6
Omeprazole3.8%47
7
Gabapentin3.6%45
8
Hydrocodone3.6%44
9
Bupropion3.5%43
10
Clonazepam3.5%43
11
Fluticasone3.5%43
12
Oxycodone3.5%43
13
Levothyroxine-sodium3.0%37
14
Modafinil3.0%37
15
Methylphenidate2.9%36

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports methamphetamine side effects

33.3% of methamphetamine adverse event reports involve female patients and 51.3% involve male patients. The largest age group is adult at 93%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.3%
Male51.3%
Unknown15.4%

Age group

< 21.2%
2–110.2%
12–171.8%
18–6493.2%
65+3.5%

What is methamphetamine used for

Conditions and purposes for which patients were taking methamphetamine when the adverse event was reported.

Attention Deficit Hyperactivity DisorderAttention Deficit/hyperactivity DisorderAttention Deficit Hyperactivity DisorderBack PainBronchitisCataplexyConvulsionCataplexyDrug AbuseDrug DependenceDrug Use For Unknown IndicationDrug Withdrawal SyndromeFatigueHypersomniaHypersomnia

Showing 15 of 29 indications

Methamphetamine brand names and reporting trend

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking methamphetamine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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