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Mestranol Side Effects

The most commonly reported side effects of mestranol include pain, injury, and nausea, based on 117 FDA adverse event reports from 2004 to 2024. 3.4% of reports found the drug to be ineffective.

Mestranol side effects

Percentages show how often each reaction appears relative to total reports for mestranol.

1
Pain5.1%6
2
Injury5.1%6
3
Nausea4.3%5
4
Breast Cancer3.4%4
5
Abdominal Pain3.4%4
6
Nausea3.4%4
7
Drug Ineffective3.4%4
8
Vomiting3.4%4
9
Off Label Use3.4%4
10
Weight Increased2.6%3
11
Dizziness2.6%3
12
Hypotension2.6%3
13
Headache2.6%3
14
Off Label Use2.6%3
15
Pulmonary Embolism2.6%3

These are voluntary reports and do not establish that mestranol caused these reactions.

Report severity

71.8%Serious84 reports
27.4%Hospitalizations32 reports
3.4%Fatal4 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mestranol drug interactions

Other drugs that appear in adverse event reports alongside mestranol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Norethindrone24.8%29
2
Ethinyl-estradiol12.0%14
3
Sodium-oxybate9.4%11
4
Drospirenone8.5%10
5
Levonorgestrel6.8%8
6
Estrogens5.1%6
7
Adalimumab4.3%5
8
Estradiol4.3%5
9
Medroxyprogesterone-acetate4.3%5
10
Desogestrel3.4%4
11
Norgestrel3.4%4
12
Progesterone3.4%4
13
Norethynodrel3.4%4
14
Ethynodiol-diacetate2.6%3
15
Venlafaxine2.6%3

Taken alongside

1
Norethindrone34.2%40
2
Acetaminophen14.5%17
3
Ibuprofen10.3%12
4
Albuterol8.5%10
5
Fluticasone8.5%10
6
Naproxen8.5%10
7
Ergocalciferol8.5%10
8
Gabapentin8.5%10
9
Omeprazole7.7%9
10
Trazodone-hydrochloride6.8%8
11
Aspirin6.8%8
12
Loratadine6.8%8
13
Clonazepam6.8%8
14
Triamcinolone6.0%7
15
Hydrochlorothiazide6.0%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mestranol side effects

90.6% of mestranol adverse event reports involve female patients and 6.0% involve male patients. The largest age group is adult at 89%. These figures reflect who reports side effects, not underlying risk.

Sex

Female90.6%
Male6.0%
Unknown3.4%

Age group

< 20.0%
2–111.4%
12–171.4%
18–6488.7%
65+8.5%

What is mestranol used for

Conditions and purposes for which patients were taking mestranol when the adverse event was reported.

Abdominal Pain UpperAmenorrhoeaContraceptionContraceptionDrug Use For Unknown IndicationDysmenorrhoeaEndometriosisHormone Replacement TherapyMenorrhagiaMenstrual DisorderMenstruation IrregularMigraineOral ContraceptionOvarian CystOvarian Endometrioid Carcinoma

Showing 15 of 18 indications

Mestranol brand names and reporting trend

Mestranol is sold under the brand name Norethindrone And Mestranol.

Brand names

Norethindrone And Mestranol35

Quarterly reports (20042024)

2005201020152024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mestranol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.