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Mepivacaine Side Effects

The most commonly reported side effects of mepivacaine include off label use, dyspnoea, and dizziness, based on 1,662 FDA adverse event reports from 2004 to 2025. 10.5% of reports found the drug to be ineffective.

Mepivacaine side effects

Percentages show how often each reaction appears relative to total reports for mepivacaine.

1
Drug Ineffective10.5%175
2
Off Label Use4.0%67
3
Dyspnoea4.0%66
4
Dizziness3.7%62
5
Nausea3.5%59
6
Hypotension3.5%58
7
Pruritus2.9%49
8
Anaphylactic Shock2.6%44
9
Seizure2.6%43
10
Vomiting2.3%38
11
Toxicity To Various Agents2.3%38
12
Hypoaesthesia2.2%36
13
Hypertension2.2%36
14
Drug Hypersensitivity2.2%36
15
Tachycardia2.0%34

These are voluntary reports and do not establish that mepivacaine caused these reactions.

Report severity

80.6%Serious1,339 reports
31.4%Hospitalizations522 reports
5.4%Fatal89 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mepivacaine drug interactions

Other drugs that appear in adverse event reports alongside mepivacaine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ropivacaine-hydrochloride8.8%147
2
Lidocaine7.4%123
3
Levonordefrin6.5%108
4
Propofol5.7%95
5
Epinephrine5.5%92
6
Bupivacaine5.2%87
7
Dexamethasone4.6%77
8
Midazolam3.7%61
9
Fentanyl3.1%51
10
Acetaminophen2.9%49
11
Triamcinolone2.2%37
12
Sevoflurane2.2%36
13
Amoxicillin2.1%35
14
Cefazolin-sodium1.9%32
15
Articaine-hydrochloride1.9%31

Taken alongside

1
Fentanyl7.7%128
2
Propofol6.9%115
3
Midazolam5.5%91
4
Acetaminophen5.1%84
5
Lidocaine4.7%78
6
Aspirin3.8%63
7
Dexamethasone3.8%63
8
Omeprazole3.7%62
9
Epinephrine3.2%54
10
Furosemide3.0%50
11
Levonordefrin2.8%47
12
Atorvastatin-calcium2.7%45
13
Ropivacaine-hydrochloride2.6%43
14
Cefazolin-sodium2.5%42
15
Levothyroxine-sodium2.5%41

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mepivacaine side effects

55.7% of mepivacaine adverse event reports involve female patients and 32.7% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.7%
Male32.7%
Unknown11.6%

Age group

< 21.4%
2–111.4%
12–171.5%
18–6460.2%
65+35.5%

What is mepivacaine used for

Conditions and purposes for which patients were taking mepivacaine when the adverse event was reported.

Abortion InducedAnaesthesiaAnaesthesia ProcedureAnaesthetic PremedicationAnalgesiaAnalgesic TherapyAnesthesia LocalArterial Bypass OperationArthralgiaArthritisArthroscopic SurgeryArtificial Crown ProcedureAbscessAllergy TestAnaesthesia

Showing 15 of 185 indications

Mepivacaine brand names and reporting trend

Mepivacaine is sold under the brand name Mepivacaine Hydrochloride W/ Levonordefrin.

Brand names

Mepivacaine Hydrochloride W/ Levonordefrin7

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mepivacaine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.