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Menadione Side Effects

The most commonly reported side effects of menadione include off label use, nausea, and sepsis, based on 685 FDA adverse event reports from 2004 to 2025.

Menadione side effects

Percentages show how often each reaction appears relative to total reports for menadione.

1
Off Label Use7.0%48
2
Nausea6.0%41
3
Sepsis5.8%40
4
Vomiting5.8%40
5
Pneumonia5.7%39
6
Pyrexia5.4%37
7
Multiple Organ Dysfunction Syndrome5.3%36
8
Fatigue4.8%33
9
Acute Kidney Injury4.8%33
10
Rash4.7%32
11
Infection4.4%30
12
Abdominal Distension4.2%29
13
Diarrhoea4.1%28
14
Abdominal Pain4.1%28
15
Ascites3.9%27

These are voluntary reports and do not establish that menadione caused these reactions.

Report severity

92.1%Serious631 reports
50.8%Hospitalizations348 reports
20.3%Fatal139 reports

Seriousness is determined by the reporter, not by OpenClaim.

Menadione drug interactions

Other drugs that appear in adverse event reports alongside menadione. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen8.9%61
2
Warfarin7.6%52
3
Ceftriaxone-sodium6.3%43
4
Lansoprazole6.3%43
5
Metronidazole6.1%42
6
Albuterol5.7%39
7
Lorazepam5.5%38
8
Sodium-chloride5.3%36
9
Epinephrine5.1%35
10
Hydrocortisone4.8%33
11
Heparin4.8%33
12
Omeprazole4.7%32
13
Potassium-chloride4.7%32
14
Simvastatin4.7%32
15
Dalteparin-sodium4.7%32

Taken alongside

1
Acetaminophen25.5%175
2
Omeprazole20.3%139
3
Furosemide19.0%130
4
Potassium-chloride13.9%95
5
Folic-acid13.7%94
6
Albuterol13.0%89
7
Ergocalciferol12.8%88
8
Ondansetron12.8%88
9
Pantoprazole-sodium12.6%86
10
Metoclopramide-hydrochloride12.4%85
11
Calcium12.3%84
12
Ascorbic-acid11.4%78
13
Sodium-chloride11.2%77
14
Vancomycin10.5%72
15
Meropenem10.2%70

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports menadione side effects

41.6% of menadione adverse event reports involve female patients and 49.8% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female41.6%
Male49.8%
Unknown8.6%

Age group

< 25.7%
2–114.2%
12–173.9%
18–6447.0%
65+39.2%

What is menadione used for

Conditions and purposes for which patients were taking menadione when the adverse event was reported.

AcneAcute Hepatic FailureAdverse EventAnticoagulant TherapyAutism Spectrum DisorderAsthmaBlood Alkaline Phosphatase IncreasedCerebellar HaemorrhageCholestasis Of PregnancyCoagulopathyCoughing BloodCystic FibrosisCholestasisDermatitis AcneiformDrug Level Increased

Showing 15 of 68 indications

Menadione brand names and reporting trend

Menadione is sold under the brand name Menadione.

Brand names

Menadione730

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking menadione with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.