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Meclofenamate Side Effects

The most commonly reported side effects of meclofenamate include drug hypersensitivity, pain, and fatigue, based on 101 FDA adverse event reports from 2004 to 2025. 5.0% of reports found the drug to be ineffective.

Meclofenamate side effects

Percentages show how often each reaction appears relative to total reports for meclofenamate.

1
Drug Hypersensitivity8.9%9
2
Pain7.9%8
3
Fatigue7.9%8
4
Nausea6.9%7
5
Myocardial Infarction5.0%5
6
Paraesthesia5.0%5
7
Pain In Extremity5.0%5
8
Drug Ineffective5.0%5
9
Arthritis4.0%4
10
Dyspnoea4.0%4
11
Malaise4.0%4
12
Hypertension4.0%4
13
Chronic Kidney Disease4.0%4
14
Arthralgia4.0%4
15
Urinary Tract Infection3.0%3

These are voluntary reports and do not establish that meclofenamate caused these reactions.

Report severity

56.4%Serious57 reports
29.7%Hospitalizations30 reports
5.0%Fatal5 reports

Seriousness is determined by the reporter, not by OpenClaim.

Meclofenamate drug interactions

Other drugs that appear in adverse event reports alongside meclofenamate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab12.9%13
2
Piroxicam6.9%7
3
Sulindac6.9%7
4
Naproxen6.9%7
5
Celecoxib5.9%6
6
Diclofenac5.9%6
7
Aspirin5.9%6
8
Etanercept5.0%5
9
Ciprofloxacin5.0%5
10
Etodolac5.0%5
11
Fenoprofen-calcium5.0%5
12
Indomethacin5.0%5
13
Rofecoxib4.0%4
14
Atorvastatin-calcium4.0%4
15
Amiodarone-hydrochloride4.0%4

Taken alongside

1
Acetaminophen23.8%24
2
Prednisone17.8%18
3
Omeprazole14.9%15
4
Levothyroxine-sodium12.9%13
5
Gabapentin11.9%12
6
Ergocalciferol11.9%12
7
Hydrochlorothiazide10.9%11
8
Folic-acid9.9%10
9
Aspirin9.9%10
10
Hydrocodone9.9%10
11
Amlodipine9.9%10
12
Lisinopril9.9%10
13
Fluticasone9.9%10
14
Ibuprofen8.9%9
15
Zolpidem-tartrate7.9%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports meclofenamate side effects

72.3% of meclofenamate adverse event reports involve female patients and 23.8% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.3%
Male23.8%
Unknown4.0%

Age group

< 20.0%
2–110.0%
12–172.6%
18–6467.5%
65+29.9%

What is meclofenamate used for

Conditions and purposes for which patients were taking meclofenamate when the adverse event was reported.

Adhesive CapsulitisArthralgiaArthritisBack DisorderDysmenorrheaIll-defined DisorderMigraineMusculoskeletal StiffnessPainProduct Used For Unknown IndicationPsoriatic ArthropathyProduct Used For Unknown IndicationRheumatoid Arthritis

Meclofenamate brand names and reporting trend

Meclofenamate is sold under the brand name Meclodium.

Brand names

Meclodium76

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking meclofenamate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.